ArticleJournal of wrist surgery2014
Carpal tunnel syndrome pathophysiology: role of subsynovial connective tissue.
Article in Journal of wrist surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Efficacy of Perineural Dextrose Versus Corticosteroid Injection for Carpal Tunnel Syndrome: A Randomized, Double-Blind Clinical Trial.Muscle & nerve · 2026Trial
- Thumb Positioning Modulates Median Nerve Mobility and Morphology During Postural Changes in Carpal Tunnel Syndrome: Implications for Nerve Gliding Exercises.Archives of rehabilitation research and clinical translation · 2026Article
- Review
- Case Report: Ultrasound-guided hydrodissection targeting the subsynovial connective tissue with dynamic ultrasound assessment in refractory carpal tunnel syndrome: a report of two cases.Frontiers in medicine · 2026Article
- Grip Force Modulation on Median Nerve Morphology Changes.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Hydrogel-Based Innovations in Carpal Tunnel Syndrome: Bridging Pathophysiological Complexities and Translational Therapeutic Gaps.Gels (Basel, Switzerland) · 2025Review
- Higher densities of T-lymphocytes in the subsynovial connective tissue of people with carpal tunnel syndrome.PloS one · 2024Article
- Current Insights into Carpal Tunnel Syndrome: Clinical Strategies for Prevention and Treatment.Current drug targets · 2024Review
- Carpal tunnel volume distribution and morphology changes with flexion-extension and radial-ulnar deviation wrist postures.PloS one · 2022Article
- Carpal tunnel syndrome treatment and the subsequent alterations in tendon and connective tissue dynamics.Clinical biomechanics (Bristol, Avon) · 2021Article
- Pathogenic Hydrogel? A Novel-Entrapment Neuropathy Model Induced by Ultrasound-Guided Perineural Injections.International journal of molecular sciences · 2021Article
- Relative Motion of the Connective Tissue in Carpal Tunnel Syndrome: The Relation with Disease Severity and Clinical Outcome.Ultrasound in medicine & biology · 2020Article
- Mutations in COMP cause familial carpal tunnel syndrome.Nature communications · 2020Article
- Wide Awake Surgery as an Opportunity to Enhance Clinical Research.Hand clinics · 2019Review
- Blocking fibrotic signaling in fibroblasts from patients with carpal tunnel syndrome.Journal of cellular physiology · 2018Review
- Thickness and Stiffness Adaptations of the Transverse Carpal Ligament Associated with Carpal Tunnel Syndrome.Journal of musculoskeletal research · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Carpal tunnel syndrome (CTS) is a very common pathology. Its most common diagnosis is idiopathic. Although it is accepted that chronic increase in pressure within the carpal tunnel is responsible for median nerve neuropathy, the exact pathophysiology leading to this pressure increase remains unknown. All the histological studies of the carpal tunnel in the CTS find a noninflammatory thickening of the subsynovial connective tissue (SSCT), which seems to be a characteristic of this pathology. Numerous animal models have been developed to recreate CTS in vivo to develop and improve preventive strategies and effective conservative treatments by a better understanding of its pathophysiology. The creation of a shear injury of the SSCT in a rabbit model induced similar modifications to what is observed in CTS, suggesting that this could be a pathway leading to idiopathic CTS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.