ArticleJournal of stem cell research & therapy2012
Generation of functional hepatic cells from pluripotent stem cells.
Article in Journal of stem cell research & therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA.Science advances · 2020Article
- Derivation and applications of human hepatocyte-like cells.World journal of stem cells · 2019Review
- Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells.Circulation research · 2018Article
- Patterning of the hepato-pancreatobiliary boundary by BMP reveals heterogeneity within the murine liver bud.Hepatology (Baltimore, Md.) · 2018Article
- A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells.Cell reports · 2018Article
- Hepatocytic differentiation of iPS cells on decellularized liver tissue.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2017Article
- Development of hepatoma-derived, bidirectional oval-like cells as a model to study host interactions with hepatitis C virus during differentiation.Oncotarget · 2017Article
- A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms.Stem cell reviews and reports · 2017Review
- Triple Staining Including FOXA2 Identifies Stem Cell Lineages Undergoing Hepatic and Biliary Differentiation in Cirrhotic Human Liver.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- Hepatocyte-like cells derived from induced pluripotent stem cells.Hepatology international · 2017Review
- Small-molecule-driven hepatocyte differentiation of human pluripotent stem cells.Stem cell reports · 2015Article
- Induced pluripotent stem cells as a source of hepatocytes.Current pathobiology reports · 2014Article
- Liver progenitor cell and KDR.Cell cycle (Georgetown, Tex.) · 2014Article
- KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.Cell stem cell · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Liver diseases affect millions of people worldwide, especially in developing country. According to the American Liver Foundation, nearly 1 in every 10 Americans suffers from some form of liver disease. Even though, the liver has great ability to self-repair, in end-stage liver diseases including fibrosis, cirrhosis, and liver cancer induced by viral hepatitis and drugs, the liver regenerative capacity is exhausted. The only successful treatment for chronic liver failure is the whole liver transplantation. More recently, some clinical trials using hepatocyte transplantation have shown some clinical improvement for metabolic liver diseases and acute liver failure. However, the shortage of donor livers remains a life-threatening challenge in liver disease patients. To overcome the scarcity of donor livers, hepatocytes generated from embryonic stem cell or induced pluripotent stem cell differentiation cultures could provide an unlimited supply of such cells for transplantation. This review provides an updated summary of hepatic differentiation protocols published so far, with a characterization of the hepatic cells generated
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.