Correlations between brachial endothelial function and cardiovascular risk factors: a survey of 2,511 Chinese subjects.

Ping-Ting Yang, Hong Yuan, Ya-Qin Wang, Xia Cao, Liu-Xin Wu, Zhi-Heng Chen

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Article in Journal of thoracic disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

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7citing papers in PubMed

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3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

Remnant cholesterol trajectory and subclinical arteriosclerosis: a 10-year longitudinal study of Chinese adults.Scientific reports · 2024
Article
Endothelial dysfunction as a factor leading to arterial hypertension.Pediatric nephrology (Berlin, Germany) · 2023
Article
The Association of Remnant Cholesterol with Endothelial Dysfunction and Subclinical Atherosclerosis in a Check-Up Population in China.Journal of atherosclerosis and thrombosis · 2023
Article
Association between Serum Uric Acid and Impaired Endothelial Function: The Circulatory Risk in Communities Study.Journal of atherosclerosis and thrombosis · 2022
Article
Proof-of-Concept Study for an Enhanced Surrogate Marker of Endothelial Function in Diabetes.Scientific reports · 2018
Article
Relation of Biochemical Parameters with Flow-mediated Dilatation in Patients with Metabolic Syndrome.Chinese medical journal · 2017
Article
Heavy Alcohol Consumption is Associated with Impaired Endothelial Function.Journal of atherosclerosis and thrombosis · 2016
Article

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5 · Who and what money

Authors and funding

6 authors.

Ping-Ting Yang1 Department of Healthy Management Center, 2 The Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.

Hong Yuan1 Department of Healthy Management Center, 2 The Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.

Ya-Qin Wang1 Department of Healthy Management Center, 2 The Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.

Xia Cao1 Department of Healthy Management Center, 2 The Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.

Liu-Xin Wu1 Department of Healthy Management Center, 2 The Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.

Zhi-Heng Chen1 Department of Healthy Management Center, 2 The Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe examined the relationship of several cardiovascular risk factors (CVRF) to brachial artery flow-mediated dilatation (FMD) in Chinese subjects.

methodsThis was a cross-sectional study. In 2,511 Chinese adults (age 46.86±9.52 years, 1,891 men and 620 women) recruited from people who underwent health screening at The Third Xiangya Hospital, patients' CVRF [age, body mass index (BMI), waist circumference (WC), blood pressure (BP), cholesterol parameters, creatinine (Cr), uric acid (UA), glucose level and smoking] and prevalence of present disease (hypertension, diabetes mellitus, coronary heart disease and hyperlipidemia) were investigated.

resultsMultivariate analysis revealed that FMD negative correlated with age (β=-0.29, P<0.001), gender (β=-0.12, P<0.001), BMI (β=-0.12, P=0.001), WC (β=-0.10, P=0.011), systolic BP (SBP) (β=-0.12, P<0.001), fasting glucose (β=-0.04, P=0.009), total cholesterol (TC) (β=-0.04, P=0.014), smoking (β=-0.05, P=0.003), and baseline brachial artery diameter (β=-0.35, P<0.001). FMD decreased with increasing age in both genders. In women, FMD was higher than men and age-related decline in FMD was steepest after age 40; FMD was similar in men above 55 years old.

conclusionsIn Chinese subjects, FMD may be a usefully marker of CVRF. Age, gender, BMI, WC, SBP, fasting glucose, TC, smoking, and baseline brachial artery diameter were independent variables related to the impairment of FMD. The influence of CVRF on endothelial function is more in women than men.

Indexed as

brachial artery flow-mediated dilatation (FMD)cardiovascular risk factors (CVRF)Endothelial function

Identifiers

PMID25364521

DOI10.3978/j.issn.2072-1439.2014.08.04

PMCPMC4215131

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.