ArticleJournal of thoracic disease2014
Experimentation with aerosol bonsetan, pirfenidone, treprostinil and sidenafil.
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Article in Journal of thoracic disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 4 citations in OpenAlex.
- Inhaled chemotherapy adverse effects: mechanisms and protection methods.Lung cancer management · 2020Review
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Authors and funding
16 authors at 1 institution in 1 country.
Haidong Huang1 Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece ; 4 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 5 II Medical Department, "Coburg" Regional Hospital, Coburg, Germany ; 6 Department of Interventional Pneumology, "Ruhrlandklinik", West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany ; 7 Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
Paul Zarogoulidis1 Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece ; 4 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 5 II Medical Department, "Coburg" Regional Hospital, Coburg, Germany ; 6 Department of Interventional Pneumology, "Ruhrlandklinik", West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany ; 7 Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
Sofia Lampaki1 Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece ; 4 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 5 II Medical Department, "Coburg" Regional Hospital, Coburg, Germany ; 6 Department of Interventional Pneumology, "Ruhrlandklinik", West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany ; 7 Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
John Organtzis1 Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece ; 4 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 5 II Medical Department, "Coburg" Regional Hospital, Coburg, Germany ; 6 Department of Interventional Pneumology, "Ruhrlandklinik", West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany ; 7 Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
Dimitris Petridis1 Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece ; 4 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 5 II Medical Department, "Coburg" Regional Hospital, Coburg, Germany ; 6 Department of Interventional Pneumology, "Ruhrlandklinik", West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany ; 7 Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
Konstantinos Porpodis1 Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece ; 4 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 5 II Medical Department, "Coburg" Regional Hospital, Coburg, Germany ; 6 Department of Interventional Pneumology, "Ruhrlandklinik", West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany ; 7 Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
Antonis Papaiwannou1 Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece ; 4 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 5 II Medical Department, "Coburg" Regional Hospital, Coburg, Germany ; 6 Department of Interventional Pneumology, "Ruhrlandklinik", West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany ; 7 Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
Vasilis Karageorgiou1 Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece ; 4 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 5 II Medical Department, "Coburg" Regional Hospital, Coburg, Germany ; 6 Department of Interventional Pneumology, "Ruhrlandklinik", West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany ; 7 Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
Georgia Pitsiou1 Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece ; 4 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 5 II Medical Department, "Coburg" Regional Hospital, Coburg, Germany ; 6 Department of Interventional Pneumology, "Ruhrlandklinik", West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany ; 7 Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
Ioannis Kioumis1 Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece ; 4 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 5 II Medical Department, "Coburg" Regional Hospital, Coburg, Germany ; 6 Department of Interventional Pneumology, "Ruhrlandklinik", West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany ; 7 Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
Wolfgang Hohenforst-Schmidt1 Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece ; 4 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 5 II Medical Department, "Coburg" Regional Hospital, Coburg, Germany ; 6 Department of Interventional Pneumology, "Ruhrlandklinik", West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany ; 7 Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
Qiang Li1 Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece ; 4 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 5 II Medical Department, "Coburg" Regional Hospital, Coburg, Germany ; 6 Department of Interventional Pneumology, "Ruhrlandklinik", West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany ; 7 Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
Kaid Darwiche1 Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece ; 4 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 5 II Medical Department, "Coburg" Regional Hospital, Coburg, Germany ; 6 Department of Interventional Pneumology, "Ruhrlandklinik", West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany ; 7 Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
Lutz Freitag1 Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece ; 4 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 5 II Medical Department, "Coburg" Regional Hospital, Coburg, Germany ; 6 Department of Interventional Pneumology, "Ruhrlandklinik", West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany ; 7 Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
Aggeliki Rapti1 Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece ; 4 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 5 II Medical Department, "Coburg" Regional Hospital, Coburg, Germany ; 6 Department of Interventional Pneumology, "Ruhrlandklinik", West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany ; 7 Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
Konstantinos Zarogoulidis1 Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece ; 4 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 5 II Medical Department, "Coburg" Regional Hospital, Coburg, Germany ; 6 Department of Interventional Pneumology, "Ruhrlandklinik", West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany ; 7 Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
Aristotle University of Thessaloniki · GR
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPulmonary hypertension (PH) has been identified either as a symptom or a primary entity. Several drugs are already on the market and other are being investigated. Idiopathic pulmonary fibrosis (IPF) is also a disease were several drugs are being investigated. MATERIALS AND
methodsThree jet nebulizers and three ultrasound nebulizers were used for our experiments with seven different residual cups and four different loadings. Bonsetan, treprostinil, sidenafil and pirfenidone were modified in order to be produced as aerosol in an effort to identify parameters which influence the droplet size production size.
resultsThe four-way ANOVA on droplet size using the jet nebulizers revealed two statistically significant factors, drug (F=6.326, P=0.0007) and residual cup (F=4.419, P=0.0007), and their interaction term (F=5.829, P<0.0001). Drugs bonsetan and pirfenidone produce equally the lowest mean droplet size (2.63 and 2.80 respectively) as compared to other two drug mean sizes. The ANOVA results, concerning the ultrasound nebulizers, revealed only the nebulizers as producing significant effect on droplet size (F=4.753, P=0.037). DISCUSSION: Our study indicates the importance of the initial drug design formulation. Moreover, further investigation of the residual cup design is an additional parameter that can assist in the optimal droplet size production, indifferently of the drug formulation.
Indexed as
aerosolbonsetaninterstitial lung fibrosispirfenidonePulmonary hypertension (PH)
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