ArticleBiology of mood & anxiety disorders2014
Reconceptualizing major depressive disorder as an infectious disease.
Article in Biology of mood & anxiety disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04528485 (The Effect of a Sea-safety Course on Mood, Mental Wellbeing and Inflammation), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of a Sea-safety Course on Mood, Mental Wellbeing and Inflammation
Who cites it
11 citing papers in PubMed.
- The Gut Microbiota and Major Depressive Disorder: Current Understanding and Novel Therapeutic Strategies.Current pharmaceutical biotechnology · 2024Review
- Imipramine Administration inPharmaceuticals (Basel, Switzerland) · 2023Article
- Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis.Cell research · 2022Article
- Fallout from the COVID-19 pandemic - should we prepare for a tsunami of post viral depression?Irish journal of psychological medicine · 2020Article
- Atypical immune response to Epstein-Barr virus in major depressive disorder.Journal of affective disorders · 2020Article
- TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease.Frontiers in immunology · 2020Review
- Inflammation, infection and depression: an evolutionary perspective.Evolutionary human sciences · 2019Article
- Do sexually transmitted infections exacerbate negative premenstrual symptoms? Insights from digital health.Evolution, medicine, and public health · 2018Article
- Cell Intrinsic Factors Modulate the Effects of IFNγ on the Development ofJournal of bacteriology & parasitology · 2016Article
- Modulation of c-Jun N-terminal kinase signaling and specific glucocorticoid receptor phosphorylation in the treatment of major depression.Medical hypotheses · 2015Article
- Sexually Transmitted Pathogens, Depression, and Other Manifestations Associated with Premenstrual Syndrome.Human nature (Hawthorne, N.Y.) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this article, I argue for a reconceptualization of major depressive disorder (major depression) as an infectious disease. I suggest that major depression may result from a parasitic, bacterial, or viral infection and present examples that illustrate possible pathways by which these microorganisms could contribute to the etiology of major depression. I also argue that the reconceptualization of the human body as an ecosystem for these microorganisms and the human genome as a host for non-human exogenous sequences may greatly amplify the opportunity to discover genetic links to the illness. Deliberately speculative, this article is intended to stimulate novel research approaches and expand the circle of researchers taking aim at this vexing illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.