ArticleChild development perspectives2014
Testing the Developmental Origins of Health and Disease Hypothesis for Psychopathology Using Family-Based Quasi-Experimental Designs.
Article in Child development perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Prenatal smoking, alcohol and caffeine exposure and offspring externalizing disorders: a systematic review and meta-analysis.Addiction (Abingdon, England) · 2022Pooled it
- Early environmental risk factors for neurodevelopmental disorders - a systematic review of twin and sibling studies.Development and psychopathology · 2021Pooled it
- Parental asthma and risk of autism spectrum disorder in offspring: A population and family-based case-control study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Causal inference in psychiatric research: how to critically evaluate and interpret mendelian randomization studies.Molecular psychiatry · 2026Review
- Observational epidemiological studies can mitigate genetic confounding with a genetic relatedness matrix.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Controlling for polygenic genetic confounding in epidemiologic association studies.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Controlling for polygenic genetic confounding in epidemiologic association studies.bioRxiv : the preprint server for biology · 2024Article
- Association between cumulative psychosocial adversity in the family and ADHD and autism: a family-based cohort study.Translational psychiatry · 2023Article
- Associations of parental and perinatal factors with subsequent risk of stress-related disorders: a nationwide cohort study with sibling comparison.Molecular psychiatry · 2022Article
- Prenatal maternal infections and children's socioemotional development: findings from the UK Millennium Cohort Study.European child & adolescent psychiatry · 2021Article
- Family-Based Designs that Disentangle Inherited Factors from Pre- and Postnatal Environmental Exposures: In Vitro Fertilization, Discordant Sibling Pairs, Maternal versus Paternal Comparisons, and Adoption Designs.Cold Spring Harbor perspectives in medicine · 2021Review
- Applying Interdisciplinary Frameworks to Study Prenatal Influences on Child Development.Child development perspectives · 2021Article
- Is association of preterm birth with cognitive-neurophysiological impairments and ADHD symptoms consistent with a causal inference or due to familial confounds?Psychological medicine · 2020Article
- Developmental programming of mitochondrial biology: a conceptual framework and review.Proceedings. Biological sciences · 2020Review
- Prenatal Developmental Origins of Future Psychopathology: Mechanisms and Pathways.Annual review of clinical psychology · 2019Review
- Impact of maternal prenatal smoking on fetal to infant neurobehavioral development.Development and psychopathology · 2018Article
- Inhibitory control in siblings discordant for exposure to maternal smoking during pregnancy.Developmental psychology · 2018Article
- Longitudinal depression or anxiety in mothers and offspring asthma: a Swedish population-based study.International journal of epidemiology · 2018Article
- Evidence-Based Practice in the social sciences? A scale of causality, interventions, and possibilities for scientific proof.Theory & psychology · 2017Article
- Sex moderates the impact of birth weight on child externalizing psychopathology.Journal of abnormal psychology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The Developmental Origin of Health and Disease (DOHaD) hypothesis is a broad theoretical framework that emphasizes how early risk factors have a causal influence on psychopathology. Researchers have raised concerns about the causal interpretation of statistical associations between early risk factors and later psychopathology because most existing studies have been unable to rule out the possibility of environmental and genetic confounding. In this paper we illustrate how family-based quasi-experimental designs can test the DOHaD hypothesis by ruling out alternative hypotheses. We review the logic underlying sibling-comparison, co-twin control, offspring of siblings/twins, adoption, and in vitro fertilization designs. We then present results from studies using these designs focused on broad indices of fetal development (low birth weight and gestational age) and a particular teratogen, smoking during pregnancy. The results provide mixed support for the DOHaD hypothesis for psychopathology, illustrating the critical need to use design features that rule out unmeasured confounding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.