ReviewDialogues in clinical neuroscience2014
Epigenetic signaling in psychiatric disorders: stress and depression.
Review in Dialogues in clinical neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 4 syntheses or guidelines pooled it, 167 citations in OpenAlex.
- A systematic review of the prevalence of fatigue in common mental disorders (mood disorders, anxiety disorders, personality disorders, and trauma and stressor related disorders).BMC psychiatry · 2026Pooled it
- An epigenome-wide association study of early-onset major depression in monozygotic twins.Translational psychiatry · 2020Pooled it
- DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies.JAMA psychiatry · 2018Pooled it
- Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness.Psychopharmacology · 2016Pooled it
- Therapeutically relevant rimonabant exposure drives epigenetic remodeling in neuronal cells and rat brain tissue.Archives of toxicology · 2026Article
- The Genetic Mosaic of Depression: Linking Polymorphisms to Neuroplasticity and Stress Regulation.Pharmaceuticals (Basel, Switzerland) · 2026Review
- The Endocannabinoid System in Human Disease: Molecular Signaling, Receptor Pharmacology, and Therapeutic Innovation.International journal of molecular sciences · 2025Review
- Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook.Frontiers in genetics · 2025Review
- Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood.Science (New York, N.Y.) · 2024Article
- Epigenetic and Coping Mechanisms of Stress in Affective Disorders: A Scoping Review.Medicina (Kaunas, Lithuania) · 2024Article
- DNA methylation differences in genes associated with human personal disorders and deviant behavior.AIMS neuroscience · 2024Article
- Epigenetic mechanisms underlying sex differences in the brain and behavior.Trends in neurosciences · 2024Review
- Review
- Prenatal Stress Induces Long-Term Behavioral Sex-Dependent Changes in Rats Offspring: the Role of the HPA Axis and Epigenetics.Molecular neurobiology · 2023Article
- Targeting the Limbic System: Insights into Its Involvement in Tinnitus.International journal of molecular sciences · 2023Review
- Early life adversity: Epigenetic regulation underlying drug addiction susceptibility.Molecular and cellular neurosciences · 2023Review
- A sex-specific genome-wide association study of depression phenotypes in UK Biobank.Molecular psychiatry · 2023Article
- Racial and Ethnic Disparities in Alcohol-Attributed Deaths in the United States, 1999-2020.International journal of environmental research and public health · 2023Article
- Potential Roles of m6A and FTO in Synaptic Connectivity and Major Depressive Disorder.International journal of molecular sciences · 2023Review
- A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression.Nutrients · 2023Review
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Psychiatric disorders are complex multifactorial disorders involving chronic alterations in neural circuit structure and function. While genetic factors play a role in the etiology of disorders such as depression, addiction, and schizophrenia, relatively high rates of discordance among identical twins clearly point to the importance of additional factors. Environmental factors, such as stress, play a major role in the psychiatric disorders by inducing stable changes in gene expression, neural circuit function, and ultimately behavior. Insults at the developmental stage and in adulthood appear to induce distinct maladaptations. Increasing evidence indicates that these sustained abnormalities are maintained by epigenetic modifications in specific brain regions. Indeed, transcriptional dysregulation and associated aberrant epigenetic regulation is a unifying theme in psychiatric disorders. Aspects of depression can be modeled in animals by inducing disease-like states through environmental manipulations, and these studies can provide a more general understanding of epigenetic mechanisms in psychiatric disorders. Understanding how environmental factors recruit the epigenetic machinery in animal models is providing new insights into disease mechanisms in humans.
Indexed as
Identifiers
25364280PMC4214172W2129161558What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.