ArticleCancer management and research2014
Higher susceptibility of NOD/LtSz-scid Il2rg (-/-) NSG mice to xenotransplanted lung cancer cell lines.
Article in Cancer management and research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Considerations for selecting immunodeficient mouse strains for cancer xenograft models.Laboratory animal research · 2026Review
- Generation of NOD SCID mice with near-complete deletions of Il2rg and Prkdc for human cancer and HSC engraftment.Transgenic research · 2025Article
- Establishment of lung cancer cell lines and tumorigenesis in mice from malignant pleural effusion in patients with lung cancer.Translational lung cancer research · 2024Article
- Article
- The Circadian Protein PER1 Modulates the Cellular Response to Anticancer Treatments.International journal of molecular sciences · 2021Article
- Comparison of biological features between severely immuno-deficient NOD/Shi-scid Il2rgExperimental animals · 2019Article
- CRISPR/Cas9-Mediated Deletion of Foxn1 in NOD/SCID/IL2rgScientific reports · 2017Article
- Hepatocyte growth factor produced in lung fibroblasts enhances non-small cell lung cancer cell survival and tumor progression.Respiratory research · 2017Article
- Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation.Scientific reports · 2017Article
- In vivo functional and morphological characterization of bone and striated muscle microcirculation in NSG mice.PloS one · 2017Article
- Human tumor infiltrating lymphocytes cooperatively regulate prostate tumor growth in a humanized mouse model.Journal for immunotherapy of cancer · 2015Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNo lung cancer xenograft model using non-obese diabetic (NOD)-scid Il2rg (-/-) mice has been reported. The purpose of this study is to select a suitable mouse strain as a xenogenic host for testing tumorigenicity of lung cancer. MATERIALS AND
methodsWe directly compared the susceptibility of four immunodeficient mouse strains, c-nu, C.B-17 scid, NOD-scid, and NOD/LtSz-scid Il2rg (-/-) (NSG) mice, for tumor formation from xenotransplanted lung cancer cell lines. Various numbers (10(1)-10(5) cells/head) of two lung cancer cell lines, A549 and EBC1, were subcutaneously inoculated and tumor sizes were measured every week up to 12 weeks.
resultsWhen 10(4) EBC1 cells were inoculated, no tumor formation was observed in BALB/c-nu or C.B-17 scid mice. Tumors developed in two of the five NOD-scid mice (40%) and in all the five NSG mice (100%). When 10(3) EBC1 cells were injected, no tumors developed in any strain other than NSG mice, while tumorigenesis was achieved in all the five NSG mice (100%, P=0.0079) within 9 weeks. NSG mice similarly showed higher susceptibility to xenotransplantation of A549 cells. Tumor formation was observed only in NSG mice after inoculation of 10(3) or fewer A549 cells (40% vs 0% in 15 NSG mice compared with others, respectively, P=0.0169). We confirmed that the engrafted tumors originated from inoculated human lung cancer cells by immunohistochemical staining with human cytokeratin and vimentin.
conclusionNSG mice may be the most suitable strain for testing tumorigenicity of lung cancer, especially if only a few cells are available.
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