ArticleDrug design, development and therapy2014
Effects of caffeic acid phenethyl ester on palatal mucosal defects and tooth extraction sockets.
Article in Drug design, development and therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Investigation of the Effect of Enamel Matrix Protein, Platelet-Rich Fibrin, and Bone Graft on New Bone Formation in Guided Tissue Regeneration in Rat Calvarium.Medicina (Kaunas, Lithuania) · 2025Article
- Caffeic acid phenethyl ester promotes palatal wound healing and enhances wound-associated macrophage CD68 expression.Journal of Taibah University Medical Sciences · 2025Article
- Investigation of the relationship between apical periodontitis and host modulation provided by nutritional supplement: a study in rats.BMC oral health · 2025Article
- The effects of Stemregen® host modulation therapy on experimentally induced apical periodontitis in rats.Journal of applied oral science : revista FOB · 2025Article
- Applications of honeybee-derived products in bone tissue engineering.Bone reports · 2024Review
- Synthetic Calcium-Phosphate Materials for Bone Grafting.Polymers · 2023Review
- Recent progresses in the pharmacological activities of caffeic acid phenethyl ester.Naunyn-Schmiedeberg's archives of pharmacology · 2021Review
- Effect of Caffeic Acid Phenethyl Ester Provision on Fibroblast Growth Factor-2, Matrix Metalloproteinase-9 Expression, Osteoclast and Osteoblast Numbers during Experimental Tooth Movement in Wistar Rats (Rattus norvegicus).European journal of dentistry · 2021Article
- A New Technique for Research on Wound Healing through Extraction of Mandibular Lower Incisors in Wistar Rats.European journal of dentistry · 2019Article
- Caffeic Acid Phenethyl Ester (CAPE) Induces VEGF Expression and Production in Rat Odontoblastic Cells.BioMed research international · 2019Article
- Effects of coenzyme QJournal of dental sciences · 2018Article
- Expression of vascular endothelial growth factor and matrix metalloproteinase-9 inVeterinary world · 2018Article
- Evaluation effect of low level Helium-Neon laser and Iranian propolis extract on Collagen Type I gene expression by human gingival fibroblasts: anLaser therapy · 2017Article
- Advantages of pure platelet-rich plasma compared with leukocyte- and platelet-rich plasma in promoting repair of bone defects.Journal of translational medicine · 2016Article
- The effects of Malaysian propolis and Brazilian red propolis on connective tissue fibroblasts in the wound healing process.BMC complementary and alternative medicine · 2015Article
- Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture.Drug design, development and therapy · 2015Article
- Effects of topical application of propolis extract on fibroblast growth factor-2 and fibroblast expression in the traumatic ulcers of diabeticJournal of oral and maxillofacial pathology : JOMFPArticle
- Protective effects of caffeic acid phenethyl ester (CAPE) and thymoquinone against cigarette smoke in experimental bone fracture healing.Journal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe purpose of this study was to evaluate the effects of caffeic acid phenethyl ester (CAPE) on palatal mucosal defects and tooth extraction sockets in an experimental model. MATERIALS AND
methodsForty-two male Sprague-Dawley rats with a mean age of 7 weeks and weighing 280-490 g were used in this study. The rats were randomly divided into two groups: group A (the control group, n=21) and group B (the experimental group, n=21). Under anesthesia with ketamine (8 mg/100 g, intraperitoneally), palatal mucosal defects were created and tooth extraction was performed in the rats in groups A and B. Group A received no treatment, whereas group B received CAPE. CAPE was injected daily (10 μmol/kg, intraperitoneally). The rats were killed on days 7, 14, and 30 after the procedures. Palatal mucosa healing and changes in bone tissue and fibrous tissue were evaluated histopathologically.
resultPairwise comparisons showed no statistically significant difference between days 7 and 14 in either group (P>0.05). At day 30, bone healing was significantly better in group B (CAPE) than in group A (control) (P<0.05). Fibrinogen levels at day 30 were significantly higher in group A (control) than in group B (CAPE) (P<0.05). Pairwise comparisons showed no statistically significant difference in palatal mucosa healing levels between days 7 and 14 in both groups (P>0.05).
conclusionIn conclusion, the findings of this study suggest that CAPE can significantly improve tooth socket healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.