ArticleAyu2014
Phytochemical screening of five medicinal legumes and their evaluation for in vitro anti-tubercular activity.
Article in Ayu, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 19 citations in OpenAlex.
- Phytochemical Composition and Antioxidant and Anti-Inflammatory Activities ofMolecules (Basel, Switzerland) · 2023Article
- Review
- Alkaloid extracts from Combretum zeyheri inhibit the growth of Mycobacterium smegmatis.BMC complementary and alternative medicine · 2017Article
- Ayurvedic management of pulmonary tuberculosis: A systematic review.Journal of intercultural ethnopharmacologyReview
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTuberculosis is a leading cause of death in the world. A new alternative for the treatment of tuberculosis is urgently required, due to the emergence of multidrug resistant Mycobacterium tuberculosis.
aimThere is currently considerable interest in developing potential drugs from medicinal plants for treating tuberculosis. To evaluate anti-tubercular activity in the leaves of Kingiodendron pinnatum Rox. Hams., Humboldtia brunonis Wall., Indigofera cassioides Rottl.ex DC., Derris scandens Benth. and Ceasalpinia mimosoides Lamk. MATERIALS AND
methodsNon-polar and polar solvent extracts of leaves of these medicinal legumes were tested against M. tuberculosis H37RV and minimum inhibitory concentrations (MICs) were determined by the agar based proportion assay.
resultsPhytochemical screening for secondary metabolites revealed the presence of saponins, steroids, anthro-quinones, terpinods, flavonoids and phlabotanins. Crude leaf extracts of these plants have shown MIC value of 50 μg/ml as against the standard drug Isoniazid value of 0.025 μg/ml.
conclusionResults showed that crude extracts of legume leaves screened exhibited potential anti-tubercular activity against M. tuberculosis and further work is required to identify the active molecule of these legumes, to get a novel anti-tubercular drug. This is the maiden finding on anti-tubercular activity of these medicinal legumes.
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