ArticleJournal of oral and maxillofacial pathology : JOMFP2014
Immunohistochemical analysis of laminin expression in adenoid cystic carcinoma.
Article in Journal of oral and maxillofacial pathology : JOMFP, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- High-Grade Solid Adenoid Cystic Carcinoma of the Larynx: A Case Report.Reports (MDPI) · 2025Article
- An Unusual Metastasis from a Rare Histology at an Atypical Location-Isolated Metachronous Scapular Metastasis from Laryngeal Adenoid Cystic Carcinoma-a Case Report.Indian journal of surgical oncology · 2020Article
- Liver metastasis from adenoid cystic carcinoma of the submandibular gland: a case report.International journal of clinical and experimental pathology · 2020Article
- Adenoid cystic carcinoma of the larynx in a 70-year-old patient: A case report.Oncology letters · 2018Article
- SPR imaging biosensor for determination of laminin-5 as a potential cancer marker in biological material.Analytical and bioanalytical chemistry · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThis study aims at the observation of the immunohistochemical expression of laminin in adenoid cystic carcinoma (ACC) of salivary gland origin and to analyze the distribution of laminin in various components of the tumor and correlate the expression of laminin with the growth and differentiation of the tumor. MATERIALS AND
methodsTHIRTY CASES OF ACC WERE SUBJECTED TO IMMUNOHISTOCHEMICAL STUDY USING POLYCLONAL ANTIHUMAN LAMININ PRIMARY ANTIBODY, DISTRIBUTION OF LAMININ IN EACH CASE OF ACC WAS OBSERVED IN THE FOLLOWING AREAS: Intracellularly, inner borders of the pseudocystic spaces, within the lumen of the pseudocysts, around the tumor islands and in the intervening stroma.
resultsLaminin positivity was observed in the inner aspect of the pseudocystic spaces in 15 cases, within the lumen of pseudocystic spaces in 22 cases, in the intervening stroma in 20 cases, bordering the tumor islands in 16 cases and intracellularly in 4 cases. INTERPRETATION AND
conclusionBased on these observations, it can be assumed that laminin plays a major role in proliferation of the tumor cells and in pseudocyst formation. Thus, laminin might play a significant role in the growth and differentiation of ACC and also help in assessing the prognosis of the tumor.
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