ArticleTrends in cell & molecular biology2013
Structural Analysis of the Key Intermediate Formed during Transcription through a Nucleosome.
Article in Trends in cell & molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Time-resolved analysis of transcription through chromatin.Methods (San Diego, Calif.) · 2019Article
- The elongation factor Spt4/5 regulates RNA polymerase II transcription through the nucleosome.Nucleic acids research · 2017Article
- Unfolding of core nucleosomes by PARP-1 revealed by spFRET microscopy.AIMS genetics · 2017Article
- Overcoming a nucleosomal barrier to replication.Science advances · 2016Article
- On the role of inter-nucleosomal interactions and intrinsic nucleosome dynamics in chromatin function.Biochemistry and biophysics reports · 2016Review
- Nucleosomal Barrier to Transcription: Structural Determinants and Changes in Chromatin Structure.Biochemistry & molecular biology journal · 2016Article
- Structural analysis of nucleosomal barrier to transcription.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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Authors and funding
6 authors.
Funding
Abstract
Transcription through chromatin by different RNA polymerases produces different biological outcomes and is accompanied by either nucleosome survival at the original location (Pol II-type mechanism) or backward nucleosome translocation along DNA (Pol III-type mechanism). It has been proposed that differences in the structure of the key intermediates formed during transcription dictate the fate of the nucleosomes. To evaluate this possibility, structure of the key intermediate formed during transcription by Pol III-type mechanism was studied by DNase I footprinting and molecular modeling. The Pol III-type mechanism is characterized by less efficient formation of the key intermediate required for nucleosome survival (Ø-loop, Pol II-type mechanism), most likely due to steric interference between the RNA polymerase and DNA in the Ø-loop. The data suggest that the lower efficiency of Ø-loop formation induces formation of a lower nucleosomal barrier and nucleosome translocation during transcription by Pol III-type mechanism.
Indexed as
Identifiers
25364155PMC4214391What OpenQuestion holds
Registered trials
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