ArticleSleep2014
Short-term potentiation in the control of pharyngeal muscles in obstructive apnea patients.
Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Mechanisms underlying the prolonged activation of the genioglossus following arousal from sleep.Sleep · 2024Article
- Enhanced expiratory rebreathing space for high loop gain sleep apnea treatment.Frontiers in sleep · 2023Review
- Sleep quality in survivors of critical illness.Sleep & breathing = Schlaf & Atmung · 2019Article
- Neural memory of the genioglossus muscle during sleep is stage-dependent in healthy subjects and obstructive sleep apnoea patients.The Journal of physiology · 2018Article
- What short-term potentiation is and why it may be relevant to obstructive sleep apnoea.The Journal of physiology · 2018Article
- Arousal-Induced Hypocapnia Does Not Reduce Genioglossus Activity in Obstructive Sleep Apnea.Sleep · 2017Article
- Article
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- Potential protective mechanism of arousal in obstructive sleep apnea.Journal of thoracic disease · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectivesTo determine if activation of the genioglossus (GG) muscle during obstructive apnea events involves short-term potentiation (STP) and is followed by sustained activation beyond the obstructive phase (after-discharge).
designPhysiological study.
settingSleep laboratory in a tertiary hospital.
participantsTwenty-one patients with obstructive apnea.
interventionsPolysomnography on continuous positive airway pressure (CPAP) with measurement of genioglossus activity. Brief dial-downs of CPAP to induce obstructive events. MEASUREMENTS AND
resultsPeak, phasic, and tonic genioglossus activities were measured breath-by-breath before, during, and following three-breath obstructions. Tonic but not phasic activity increased immediately following the first obstructed breath (4.9 ± 1.6 versus 3.6 ± 1.2 %GGMAX; P = 0.01) under conditions where stimuli to genioglossus activation were likely constant, strongly implicating STP in mediating recruitment of tonic activity. Both phasic and tonic activities declined slowly after relief of obstruction (after-discharge). Decay time constants were systematically shorter for phasic than for tonic activity (7.5 ± 3.8 versus 18.1 ± 8.4 sec; P < 0.001). Decay time-constant of peak activity correlated with tonic, but not phasic, recruitment. Cortical arousal near the end of obstruction resulted in a lower after-discharge (P < 0.01). Contribution of tonic activity to the increase in peak activity (6-65%Peak), as well as the decay constant (6-30 sec), varied considerably among patients.
conclusionsShort-term potentiation contributes to recruitment of the genioglossus during obstructive episodes and results in sustained tonic activity beyond the obstructive phase, thereby potentially preventing recurrence of obstruction. Wide response differences among subjects suggest that this mechanism may contribute to severity of the disorder. The after-discharge is inhibited following cortical arousal, potentially explaining arousals' destabilizing effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.