ArticleCirculation. Cardiovascular genetics2014
Human plasma lipidome is pleiotropically associated with cardiovascular risk factors and death.
Article in Circulation. Cardiovascular genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion inCirculation. Genomic and precision medicine · 2021Trial
- Cutting Edge: Severe SARS-CoV-2 Infection in Humans Is Defined by a Shift in the Serum Lipidome, Resulting in Dysregulation of Eicosanoid Immune Mediators.Journal of immunology (Baltimore, Md. : 1950) · 2021Trial
- Heritability and responses to high fat diet of plasma lipidomics in a twin study.Scientific reports · 2017Trial
- Population-based genome-wide association study of plasma complex lipid species.Nature communications · 2026Article
- Blood lipidome profiling reveals potential biomarkers linked to health and carcass quality traits in pigs.Genetics, selection, evolution : GSE · 2026Article
- Comprehensive Genetic Map of Muscle Lipidome Reveals Novel Insights Into Flavor Variation in Ruminant Meat.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Longitudinal lipidomic signatures of all-cause and CVD mortality in American Indians: findings from the Strong Heart Study.GeroScience · 2023Article
- Proteomics and lipidomics in atherosclerotic cardiovascular disease risk prediction.European heart journal · 2023Article
- A dominant negative ADIPOQ mutation in a diabetic family with renal disease, hypoadiponectinemia, and hyperceramidemia.NPJ genomic medicine · 2022Article
- Article
- An Amish founder population reveals rare-population genetic determinants of the human lipidome.Communications biology · 2022Article
- Lipidomics in Understanding Pathophysiology and Pharmacologic Effects in Inflammatory Diseases: Considerations for Drug Development.Metabolites · 2022Review
- The Prevalence of Polycystic Ovary Syndrome, Its Phenotypes and Cardio-Metabolic Features in a Community Sample of Iranian Population: Tehran Lipid and Glucose Study.Frontiers in endocrinology · 2022Article
- Influence of the Human Lipidome on Epicardial Fat Volume in Mexican American Individuals.Frontiers in cardiovascular medicine · 2022Article
- Genomics of Postprandial Lipidomics in the Genetics of Lipid-Lowering Drugs and Diet Network Study.Nutrients · 2021Article
- Multi-omic Analysis of Non-human Primate Heart after Partial-body Radiation with Minimal Bone Marrow Sparing.Health physics · 2021Article
- Distinct Fatty Acid Compositions of HDL Phospholipids Are Characteristic of Metabolic Syndrome and Premature Coronary Heart Disease-Family Study.International journal of molecular sciences · 2021Article
- Heritability and family-based GWAS analyses of the N-acyl ethanolamine and ceramide plasma lipidome.Human molecular genetics · 2021Article
- Integrating lipidomics and genomics: emerging tools to understand cardiovascular diseases.Cellular and molecular life sciences : CMLS · 2021Review
- Genetic association of anthropometric traits with type 2 diabetes in ethnically endogamous Sindhi families.PloS one · 2021Article
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18 authors.
Funding
Abstract
backgroundCardiovascular disease (CVD) is the most common cause of death in the United States and is associated with a high economic burden. Prevention of CVD focuses on controlling or improving the lipid profile of patients at risk. The human lipidome is made up of thousands of ubiquitous lipid species. By studying biologically simple canonical lipid species, we investigated whether the lipidome is genetically redundant and whether its genetic influences can provide clinically relevant clues of CVD risk. METHODS AND
resultsWe performed a genetic study of the human lipidome in 1212 individuals from 42 extended Mexican American families. High-throughput mass spectrometry enabled rapid capture of precise lipidomic profiles, providing 319 unique species. Using variance component-based heritability analyses and bivariate trait analyses, we detected significant genetic influences on each lipid assayed. Median heritability of the plasma lipid species was 0.37. Hierarchical clustering based on complex genetic correlation patterns identified 12 genetic clusters that characterized the plasma lipidome. These genetic clusters were differentially but consistently associated with risk factors of CVD, including central obesity, obesity, type 2 diabetes mellitus, raised serum triglycerides, and metabolic syndrome. Also, these clusters consistently predicted occurrence of cardiovascular deaths during follow-up.
conclusionsThe human plasma lipidome is heritable. Shared genetic influences reduce the dimensionality of the human lipidome into clusters that are associated with risk factors of CVD.
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