ArticleACS nano2014
Probing solid-state nanopores with light for the detection of unlabeled analytes.
Article in ACS nano, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 70 citations in OpenAlex.
- Interrogating nanopores with light: optipore sensing for single molecule analyses.Journal of nanobiotechnology · 2026Review
- Site-Specific Integration of Hexagonal Boron Nitride Quantum Emitters on 2D DNA Origami Nanopores.Nano letters · 2024Article
- Localized Nanopore Fabrication via Controlled Breakdown.Nanomaterials (Basel, Switzerland) · 2022Review
- Docking and Activity of DNA Polymerase on Solid-State Nanopores.ACS sensors · 2022Article
- Enhanced Optical Spectroscopy for Multiplexed DNA and Protein-Sequencing with Plasmonic Nanopores: Challenges and Prospects.Analytical chemistry · 2022Article
- Understanding Electrical Conduction and Nanopore Formation During Controlled Breakdown.Small (Weinheim an der Bergstrasse, Germany) · 2021Article
- Engineering improved measurement and actuation for nanoscale biophysics.Biophysical reviews · 2020Article
- Microfluidic Systems Applied in Solid-State Nanopore Sensors.Micromachines · 2020Review
- Electrode-free nanopore sensing by DiffusiOptoPhysiology.Science advances · 2019Article
- Article
- Optically-Monitored Nanopore Fabrication Using a Focused Laser Beam.Scientific reports · 2018Article
- Optofluidic devices with integrated solid-state nanopores.Mikrochimica acta · 2016Article
- High-throughput optical sensing of nucleic acids in a nanopore array.Nature nanotechnology · 2015Article
- Article
- Two color DNA barcode detection in photoluminescence suppressed silicon nitride nanopores.Nano letters · 2015Article
- Genomic Pathogen Typing Using Solid-State Nanopores.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Nanopore sensing has enabled label-free single-molecule measurements on a wide variety of analytes, including DNA, RNA, and protein complexes. Much progress has been made toward biotechnological applications; however, electrically probing the ion current introduces nonideal noise components. Here we further develop a method to couple an ionic current to a photon-by-photon counting of fluorescent signal from Ca(2+)-sensitive dyes and demonstrate label-free optical detection of biopolymer translocation through solid-state nanopores using TIRF and confocal microscopy. We show that by fine adjustment of the CaCl2 gradient, EGTA concentration, and voltage, the optical signals can be localized to the immediate vicinity of the pore. Consequently, the noise spectral density distribution in the optical signal exhibits a nearly flat distribution throughout the entire frequency range. With the use of high-speed photon counting devices in confocal microscopy and higher photon count rates using stronger light sources, we can improve the signal-to-noise ratio of signal acquisition, while the use of wide-field imaging in TIRF can allow for simultaneous quantitative imaging of large arrays of nanopores.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.