SynthesisLeukemia2015
Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia risk.
Open access · hybridAbstract readLetterMeta-Analysis
In one paragraph
Synthesis in Leukemia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 21% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Role of Polygenic Risk Score in Cancer Precision Medicine of Non-European Populations: A Systematic Review.Current oncology (Toronto, Ont.) · 2022Pooled it
- Common genetic polymorphisms contribute to the association between chronic lymphocytic leukaemia and non-melanoma skin cancer.International journal of epidemiology · 2021Pooled it
- Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.Nature communications · 2016Pooled it
- The FunctionalInternational journal of molecular sciences · 2026Article
- In-silico identification of genetic variants associated with chronic lymphocytic leukemia for diagnostic and therapeutic applications.Scientific reports · 2026Article
- The expression signature, prognostic significance and immune cell infiltration of the OAS gene family in gastric cancer.Scientific reports · 2025Article
- Integration of Germline and Somatic Variation Improves Chronic Lymphocytic Leukemia Risk Stratification.Cancer research · 2025Article
- CAT rs1001179 Single Nucleotide Polymorphism Identifies an Aggressive Clinical Behavior in Chronic Lymphocytic Leukemia.Hematological oncology · 2024Article
- Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer.BMC cancer · 2022Article
- Article
- Consistent B Cell Receptor Immunoglobulin Features Between Siblings in Familial Chronic Lymphocytic Leukemia.Frontiers in oncology · 2021Article
- Tracking the Genetic Susceptibility Background of B-Cell Non-Hodgkin's Lymphomas from Genome-Wide Association Studies.International journal of molecular sciences · 2020Review
- Chronic lymphocytic leukemia (CLL) risk is mediated by multiple enhancer variants within CLL risk loci.Human molecular genetics · 2020Article
- Systems biology comprehensive analysis on breast cancer for identification of key gene modules and genes associated with TNM-based clinical stages.Scientific reports · 2020Article
- Identification and characterization of biomarkers and their functions for docetaxel-resistant prostate cancer cells.Oncology letters · 2019Article
- Defects in interferon pathways as potential biomarkers of sensitivity to oncolytic viruses.Reviews in medical virology · 2018Review
- Article
- Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.Nature communications · 2017Article
- Germ line mutations in shelterin complex genes are associated with familial chronic lymphocytic leukemia.Blood · 2016Article
- Nuclear import sequence identification in hOAS3 protein.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors at 20 institutions in 4 countries.
G P SavaDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK.
H E SpeedyDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK.
M C Di BernardoDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK.
M J S DyerThe Ernest and Helen Scott Haematological Research Institute, Department of Biochemistry and Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK.
A HolroydDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK.
N J SunterNorthern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
H MarrNorthern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
L MansouriDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
S DeaglioDepartment of Medical Sciences and Human Genetics Foundation, University of Turin, Turin, Italy.
L Karabon1] Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland [2] Department and Clinic of Urology, Wroclaw Medical University, Wroclaw, Poland.
I FrydeckaDepartment of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
K JamroziakDepartment of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.
D WoszczykDepartment of Haematology, State Hospital, Opole, Poland.
G JuliussonLund Strategic Research Center for Stem Cell Biology and Cell Therapy, Hematology and Transplantation, Lund University, Lund, Sweden.
K E SmedbyUnit of Clinical Epidemiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
S JayneThe Ernest and Helen Scott Haematological Research Institute, Department of Biochemistry and Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK.
A MajidMedical Research Council Toxicology Unit, Leicester University, Leicester, UK.
Y WangDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK.
C DeardenHaemato-Oncology, Division of Pathology, The Institute of Cancer Research, Sutton, UK.
A G HallNorthern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
T Mainou-FowlerHaematological Sciences, Medical School, Newcastle University, Newcastle upon Tyne, UK.
G H JacksonDepartment of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
G SummerfieldDepartment of Haematology, Queen Elizabeth Hospital, Gateshead, Newcastle upon Tyne, UK.
R J HarrisDepartment of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.
A R PettittDepartment of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.
D J AllsupDepartment of Haematology, Hull Royal Infirmary, Hull, UK.
J R BaileyHull York Medical School and University of Hull, Hull, UK.
G PrattDepartment of Haematology, Birmingham Heartlands Hospital, Birmingham, UK.
C PepperDepartment of Haematology, School of Medicine, Cardiff University, Cardiff, UK.
C FeganCardiff and Vale National Health Service Trust, Heath Park, Cardiff, UK.
R RosenquistDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
D CatovskyHaemato-Oncology, Division of Pathology, The Institute of Cancer Research, Sutton, UK.
J M AllanNorthern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
R S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK.
Institute of Cancer Research · GBNewcastle University · GBUniversity of Leicester · GBUniversity of Liverpool · GBCardiff and Vale University Health Board · GBCardiff University · GBHeartlands Hospital · GBHull Royal Infirmary · GBHull York Medical School · GBInstytut Hematologii i Transfuzjologi · PLKarolinska Institutet · SELund University · SEMedical Research Council · GBPolish Academy of Sciences · PLQueen Elizabeth Hospital · GBRoyal Victoria Infirmary · GBScience for Life Laboratory · SEUniversity of Opole · PLUniversity of Turin · ITUppsala University · SE
Funding
Cancer Research UK 15116Cancer Research UK C1298/A8362Wellcome Trust
Abstract
PubMed holds no abstract for this paper.
Indexed as
IntronsPolymorphism, Single Nucleotide2',5'-Oligoadenylate SynthetaseAllelesCase-Control StudiesChromosome MappingChromosomes, Human, Pair 12Gene FrequencyGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLeukemia, Lymphocytic, Chronic, B-CellOdds RatioRisk2',5'-Oligoadenylate SynthetaseOAS3 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.