ArticleAddiction biology2016
Cocaine can generate a stronger conditioned reinforcer than food despite being a weaker primary reinforcer.
Article in Addiction biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Characterization of Neuronal Ensembles in a Model of Dual-Reward Conditioned Place Preference.eNeuro · 2026Article
- A Review of Behavioral Economic Manipulations Affecting Drug versus Nondrug Choice in Rats.Perspectives on behavior science · 2025Review
- Formation of an Enduring Ensemble of Accumbens Neurons Leads to Prepotent Seeking for Cocaine Over Natural Reward Cues.bioRxiv : the preprint server for biology · 2024Article
- Neuropathic pain has sex-specific effects on oxycodone-seeking and non-drug-seeking ensemble neurons in the dorsomedial prefrontal cortex of mice.Addiction biology · 2024Article
- Nucleus accumbens neuronal ensembles vary with cocaine reinforcement in male and female rats.Addiction biology · 2024Article
- Drug memory reconsolidation: from molecular mechanisms to the clinical context.Translational psychiatry · 2023Review
- Intermittent access training produces greater motivation for a non-drug reinforcer than long access training.Learning & behavior · 2022Article
- Memory enhancing effects of nicotine, cocaine, and their conditioned stimuli; effects of beta-adrenergic and dopamine D2 receptor antagonists.Psychopharmacology · 2021Article
- Animal Models of the Behavioral Symptoms of Substance Use Disorders.Cold Spring Harbor perspectives in medicine · 2021Review
- Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Cocaine and sucrose rewards recruit different seeking ensembles in the nucleus accumbens core.Molecular psychiatry · 2020Article
- Heroin choice depends on income level and economy type.Psychopharmacology · 2020Article
- Non-pharmacological factors that determine drug use and addiction.Neuroscience and biobehavioral reviews · 2020Review
- The effect of economy type on heroin and saccharin essential value.Experimental and clinical psychopharmacology · 2019Article
- Article
- Cocaine, nicotine, and their conditioned contexts enhance consolidation of object memory in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Understanding Addiction Using Animal Models.Frontiers in behavioral neuroscience · 2019Article
- The effect of economy type on demand and preference for cocaine and saccharin in rats.Drug and alcohol dependence · 2018Article
- The effect of nicotine pre-exposure on demand for cocaine and sucrose in male rats.Behavioural pharmacology · 2018Article
- Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The present study aimed to test the hypothesis that cues associated with drug-taking behavior become extra strong motivators of behavior compared with cues paired with non-drug reinforcers. In experiment 1, rats were trained to lever press for intravenous cocaine infusions and grain pellets. Each reinforcer was paired with a distinct audiovisual cue. When allowed to choose between these alternatives, rats chose grain on ~70-80 percent of trials. However, after extinguishing lever pressing, reintroduction of press-contingent cues during a test for cue-induced reinstatement generated more cocaine seeking than grain seeking (also observed on 3- and 8-week follow-up tests). To examine whether the same pattern of results would occur with two non-drug reinforcers, experiment 2 replicated experiment 1 using grain and sucrose as reinforcement alternatives. Rats chose sucrose over grain on ~70-80 percent of choice trials and also responded more for the sucrose cue than for the grain cue on the reinstatement test. The disconnect between primary and conditioned reinforcements in experiment 1 but not in experiment 2 suggests that drug cues may become exceptionally strong motivators of drug seeking. These results are consistent with cue-focused theories of addiction and may offer insight into the persistent cue-driven drug-seeking behavior observed in addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.