ReviewTransplant international : official journal of the European Society for Organ Transplantation2015
Thymoglobulin induction in heart transplantation: patient selection and implications for maintenance immunosuppression.
Review in Transplant international : official journal of the European Society for Organ Transplantation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Pooled it
- A stage-based framework to interpret regulatory T cell biology after heart transplantation.Frontiers in cardiovascular medicine · 2026Review
- Cumulative weight-based rabbit antithymocyte globulin dosing for induction in heart transplantation: Impact on outcomes.JHLT open · 2025Article
- Kinetics of Procalcitonin, CRP, IL-6, and Presepsin in Heart Transplant Patients Undergoing Induction with Thymoglobulin (rATG).Journal of clinical medicine · 2025Article
- The Effect of Early Spironolactone Administration on 2-Year Acute Graft Rejection in Cardiac Transplant Patients.Biomedicines · 2025Article
- Antithymocyte Globulin Inhibits CD8Cells · 2023Article
- Kidney disease in non-kidney solid organ transplantation.World journal of transplantation · 2022Review
- Retrospective Evaluation of Rabbit Antithymocyte Globulin Induction in Heart Transplant Patients.Transplantation direct · 2022Article
- Extracorporeal Photopheresis With Low-Dose Immunosuppression in High-Risk Heart Transplant Patients-A Pilot Study.Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- Induction Immunosuppression and Renal Outcomes in Adult Heart Transplantation.The Journal of surgical research · 2021Article
- Immunosuppression trends in solid organ transplantation: The future of individualization, monitoring, and management.Pharmacotherapy · 2021Review
- Cardiac transplantation in children.BJA education · 2019Review
- Clinical phenomapping and outcomes after heart transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2018Article
- Outcomes of Induction Therapy with Rabbit Anti-Thymocyte Globulin in Heart Transplant Recipients: A Single Center Retrospective Cohort Study.Annals of transplantation · 2018Article
- A Review of Induction with Rabbit Antithymocyte Globulin in Pediatric Heart Transplant Recipients.Annals of transplantation · 2018Review
- A Proposal for Early Dosing Regimens in Heart Transplant Patients Receiving Thymoglobulin and Calcineurin Inhibition.Transplantation direct · 2016Review
- Desensitization Strategies Pre- and Post-Cardiac Transplantation.Current treatment options in cardiovascular medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical data relating to rabbit antithymocyte globulin (rATG) induction in heart transplantation are far less extensive than for other immunosuppressants, or indeed for rATG in other indications. This was highlighted by the low grade of evidence and the lack of detailed recommendations for prescribing rATG in the International Society for Heart and Lung Transplantation (ISHLT) guidelines. The heart transplant population includes an increasing frequency of patients on mechanical circulatory support (MCS), often with ongoing infection and/or presensitization, who are at high immunological risk but also vulnerable to infectious complications. The number of patients with renal impairment is also growing due to lengthening waiting times, intensifying the need for strategies that minimize calcineurin inhibitor (CNI) toxicity. Additionally, the importance of donor-specific antibodies (DSA) in predicting graft failure is influencing immunosuppressive regimens. In light of these developments, and in view of the lack of evidence-based prescribing criteria, experts from Germany, Austria, and Switzerland convened to identify indications for rATG induction in heart transplantation and to develop an algorithm for its use based on patient characteristics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.