ArticleMetallomics : integrated biometal science2015
Endothelial responses of magnesium and other alloying elements in magnesium-based stent materials.
Article in Metallomics : integrated biometal science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 100 citations in OpenAlex.
- A mild photothermal-mediated neuroimmunomodulatory composite hydrogel reverses the inflammatory osteoclast precursor phenotype to promote osteoporotic bone defect healing.Bioactive materials · 2026Article
- Ionic Extracts of Magnesium Powders Promote In Vitro Lymphangiogenesis.Biomedicines · 2026Article
- A bioactive hydrogel patch accelerates revascularization in ischemic lesions for tissue repair.Burns & trauma · 2025Article
- Regression models for the prediction of the influence of magnesium ions on primary endothelial cell (HUVEC) proliferation and migration.Computational and structural biotechnology journal · 2025Article
- Benchtop proof of concept and comparison of iron- and magnesium-based bioresorbable flow diverters.Journal of neurosurgery · 2023Article
- In Vitro and In Vivo Applications of Magnesium-Enriched Biomaterials for Vascularized Osteogenesis in Bone Tissue Engineering: A Review of Literature.Journal of functional biomaterials · 2023Review
- An In Vivo Rat Study of Bioresorbable Mg-2Zn-2Ga Alloy Implants.Bioengineering (Basel, Switzerland) · 2023Article
- Mg-based materials diminish tumor spreading and cancer metastases.Bioactive materials · 2023Article
- Simulating In Vitro the Bone Healing Potential of a Degradable and Tailored Multifunctional Mg-Based Alloy Platform.Bioengineering (Basel, Switzerland) · 2022Article
- The Flow-Induced Degradation and Vascular Cellular Response Study of Magnesium-Based Materials.Frontiers in bioengineering and biotechnology · 2022Article
- Investigation on tribological behaviors of biodegradable pure Zn and Zn-X (Li, Cu, Ge) binary alloys.Journal of materials science. Materials in medicine · 2021Article
- Resorbable MgMaterials (Basel, Switzerland) · 2021Review
- An ex vivo physiologic and hyperplastic vessel culture model to study intra-arterial stent therapies.Biomaterials · 2021Article
- The biological responses and mechanisms of endothelial cells to magnesium alloy.Regenerative biomaterials · 2021Article
- Corrosion Behavior and Biocompatibility of Diamond-like Carbon-Coated Zinc: An In Vitro Study.ACS omega · 2021Article
- Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesisBioactive materials · 2020Article
- Salt Preform Texturing of Absorbable Zn Substrates for Bone-implant Applications.JOM (Warrendale, Pa. : 1989) · 2020Article
- Evolution of metallic cardiovascular stent materials: A comparative study among stainless steel, magnesium and zinc.Biomaterials · 2020Article
- Alloying design of biodegradable zinc as promising bone implants for load-bearing applications.Nature communications · 2020Article
- Enhanced cytocompatibility and antibacterial property of zinc phosphate coating on biodegradable zinc materials.Acta biomaterialia · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Biodegradable tailored magnesium (Mg) alloys are some of the most promising scaffolds for cardiovascular stents. During the course of degradation after implantation, all the alloying elements in the scaffold will be released to the surrounding vascular tissues. However, fundamental questions regarding the toxicity of alloying elements towards vascular cells, the maximum amount of each element that could be used in alloy design, or how each of the alloying elements affects vascular cellular activity and gene expression, are still not fully answered. This work systematically addressed these questions by revealing how application of different alloying elements commonly used in Mg stent materials influences several indices of human endothelial cell health, i.e., viability, proliferations, cytoskeletal reorganizations, migration, and the gene expression profile. The overall cell viability and proliferation showed a decreasing trend with increasing concentrations of the ions, and the half maximal effective concentrations (EC50) for each element were determined. When applied at a low concentration of around 10 mM, Mg had no adverse effects but improved cell proliferation and migration instead. Mg ions also altered endothelial gene expression significantly in a dose dependent manner. Most of the changed genes are related to angiogenesis and the cell adhesion signaling pathways. Findings from this work provide useful information on maximum safe doses of these ions for endothelial cells, endothelial responses towards these metal ions, and some guidance for future Mg stent design.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.