ReviewCNS oncology2014
Stem cell niche irradiation in glioblastoma: providing a ray of hope?
Review in CNS oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Assessment of subventricular zone irradiation in glioblastoma patients.Frontiers in oncology · 2026Article
- Multi-modal fusion and feature enhancement U-Net coupling with stem cell niches proximity estimation for voxel-wise GBM recurrence predictionPhysics in medicine and biology · 2024Article
- Voxelwise Prediction of Recurrent High-Grade Glioma via Proximity Estimation-Coupled Multidimensional Support Vector Machine.International journal of radiation oncology, biology, physics · 2022Article
- Review
- The Role of SVZ Stem Cells in Glioblastoma.Cancers · 2019Review
- Location-Dependent Patient Outcome and Recurrence Patterns in IDH1-Wildtype Glioblastoma.Cancers · 2019Article
- Subventricular Zone Radiation Dose and Outcome for Glioblastoma Treated Between 2006 and 2012.Cureus · 2018Article
- Subventricular zone involvement at recurrence is a strong predictive factor of outcome following high grade glioma reirradiation.Journal of neuro-oncology · 2018Article
- Influence of incidental radiation dose in the subventricular zone on survival in patients with glioblastoma multiforme treated with surgery, radiotherapy, and temozolomide.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017Article
- Hypoxia-Mediated Mechanisms Associated with Antiangiogenic Treatment Resistance in Glioblastomas.The American journal of pathology · 2017Review
- Subventricular zones: new key targets for glioblastoma treatment.Radiation oncology (London, England) · 2017Article
- Advances in Radiotherapy for Glioblastoma.Frontiers in neurology · 2017Review
- Neural stem cells, the subventricular zone and radiotherapy: implications for treating glioblastoma.Journal of neuro-oncology · 2016Review
- Subventricular zone-associated glioblastoma: A call for translational research to guide clinical decision making.Neurogenesis (Austin, Tex.) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glioblastomas are organized hierarchically with a small number of glioblastoma stem cells that have unique self-renewal capacity and multilineage potency. The subventricular zone (SVZ) constitutes the largest neural stem cell niche in the adult human brain; it may also act as a reservoir of glioblastoma stem cells that can initiate, promote or repopulate a tumor. Incidental irradiation of SVZ has been shown to potentially influence outcomes suggesting that aggressively targeting the stem cell niche may offer a ray of hope in glioblastoma. The following review provides a summary of the experimental evidence supporting the origin and location of the putative glioblastoma stem cell in the SVZ, and offers a critical appraisal of the growing body of clinical evidence correlating SVZ dosimetry with outcomes in glioblastoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.