Evidence map›Paper›PMID 25362638›Full record

ReviewPhysiology (Bethesda, Md.)2014

Making microvascular networks work: angiogenesis, remodeling, and pruning.

Axel R Pries, Timothy W Secomb

Abstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed.

  1. Article
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  3. Review
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  7. Review
  8. Article
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  11. Article
  12. Article
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  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Axel R PriesDepartment of Physiology and CCR, Charité, Berlin, Germany; Deutsches Herzzentrum Berlin, Berlin, Germany; axel.pries@charite.de.
Timothy W SecombDepartment of Physiology, University of Arizona, Tucson, Arizona.

Funding

MICROVASCULAR BLOOD RHEOLOGY &RED BLOOD CELL MECHANICSR01HL034555 · NHLBI · UNIVERSITY OF ARIZONA · PI SECOMB, TIMOTHY W. · 1988 to 2020
$3.2M
MICROVASCULAR BLOOD RHEOLOGY &RED BLOOD CELL MECHANICSR23HL034555 · NHLBI · UNIVERSITY OF ARIZONA · PI SECOMB, TIMOTHY W. · 1985 to 1987
–
NHLBI NIH HHS HL-034555NHLBI NIH HHS R01 HL034555
6 · The paper itself

Abstract

The adequate and efficient functioning of the microcirculation requires not only numerous vessels providing a large surface area for transport but also a structure that provides short diffusion distances from capillaries to tissue and efficient distribution of convective blood flow. Theoretical models show how a combination of angiogenesis, remodeling, and pruning in response to hemodynamic and metabolic stimuli, termed "angioadaptation," generates well organized, functional networks.

Indexed as

MicrocirculationModels, CardiovascularNeovascularization, PhysiologicAdaptation, PhysiologicalAnimalsDiffusionHemodynamicsHumansMicrovesselsNeovascularization, Pathologic

Identifiers

PMID25362638
PMCPMC4280154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.