Evidence map›Paper›PMID 25362637›Full record

ReviewPhysiology (Bethesda, Md.)2014

Exercise, neurotrophins, and axon regeneration in the PNS.

Arthur W English, Jennifer C Wilhelm, Patricia J Ward

Abstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Molecular mechanisms of exercise contributing to tissue regeneration.Signal transduction and targeted therapy · 2022
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Arthur W EnglishDepartment of Cell Biology, Emory University School of Medicine, Atlanta, Georgia; and medae@emory.edu.
Jennifer C WilhelmDepartment of Psychology, College of Charleston, Charleston, South Carolina.
Patricia J WardDepartment of Cell Biology, Emory University School of Medicine, Atlanta, Georgia; and.

Funding

SPINAL CIRCUITS &THE MUSCULOSKELETAL SYSTEMP01HD032571 · NICHD · EMORY UNIVERSITY · PI NICHOLS, T. RICHARD · 1995 to 2016
$16.2M
Exercise, neurotrophins, and axon regeneration in the PNSR01NS057190 · NINDS · EMORY UNIVERSITY · PI ENGLISH, ARTHUR W. · 2007 to 2016
$3.3M
NICHD NIH HHS HD-032571NICHD NIH HHS P01 HD032571NINDS NIH HHS NS-057190NINDS NIH HHS R01 NS057190
6 · The paper itself

Abstract

Electrical stimulation and exercise are treatments to enhance recovery from peripheral nerve injuries. Brain-derived neurotrophic factor and androgen receptor signaling are requirements for the effectiveness of these treatments. Increased neuronal activity is adequate to promote regeneration in injured nerves, but the dosing of activity and its relationship to neurotrophins and sex steroid hormones is less clear. Translation of these therapies will require principles associated with their cellular mechanisms.

Indexed as

AxonsElectric Stimulation TherapyExercise TherapyNerve RegenerationAnimalsFemaleGonadal Steroid HormonesHumansMaleNerve Growth FactorsPeripheral Nerve InjuriesPeripheral NervesRecovery of FunctionSignal TransductionTreatment OutcomeGonadal Steroid HormonesNerve Growth Factors

Identifiers

PMID25362637
PMCPMC4280152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.