ArticleFamilial cancer2015
Single nucleotide polymorphisms in PDCD6 gene are associated with the development of cervical squamous cell carcinoma.
Article in Familial cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Association between PDCD6-VNTR polymorphism and urinary cancer susceptibility.Genes & genomics · 2024Article
- Identification of novel genomic hotspots and tumor-relevant genes via comprehensive analysis of HPV integration in Chinese patients of cervical cancer.American journal of cancer research · 2024Article
- Contribution of programmed cell death 6 genetic variations, gender, and smoking status to lung cancer.OncoTargets and therapy · 2019Article
- microRNA-124-3p inhibits the progression of congenital hypothyroidism via targeting programmed cell death protein 6.Experimental and therapeutic medicine · 2018Article
- Association of PDCD6 polymorphisms with the risk of cancer: Evidence from a meta-analysis.Oncotarget · 2018Review
- MiR-124 inhibits invasion and induces apoptosis of ovarian cancer cells by targeting programmed cell death 6.Oncology letters · 2017Article
- MicroRNA-183 promotes cell proliferation via regulating programmed cell death 6 in pediatric acute myeloid leukemia.Journal of cancer research and clinical oncology · 2017Article
- The Contribution of PDCD6 Polymorphisms to Oral Cancer Risk.Cancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The programmed cell death 6 (PDCD6), discovered as a proapoptotic calcium-binding protein, has recently been found dysregulated in tumors of various origin and contributed to cancer cell viability. The aim of this study was to determine whether SNPs in PDCD6 are associated with cervical squamous cell carcinoma (CSCC). Polymerase chain reaction-restriction fragment length polymorphism method was used to genotype two tag SNPs (rs3756712 and rs4957014) of PDCD6 in 328 CSCC patients and 541 controls. Significantly increased CSCC risks were found to be associated with T allele of rs3756712 and G allele of rs4957014 (P = 0.017, OR = 1.320, and P = 0.007, OR = 1.321, respectively). CSCC risks were associated with these two SNPs in different genetic model (P = 0.04, OR = 1.78 for rs3756712 in a recessive model, and P = 0.006, OR = 2.01 for rs4957014 in a codominant model, respectively). Results of stratified analyses revealed that rs4957014 is associated with parametrial invasion of CSCC (P = 0.044, OR = 1.414). Our results suggest that these two tag SNPs of PDCD6 are associated with CSCC, indicating that PDCD6 may play an important role in the pathogenesis of CSCC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.