ArticleInternational archives of occupational and environmental health2015
Micronuclei and chromosome aberrations in subjects occupationally exposed to antineoplastic drugs: a multicentric approach.
Article in International archives of occupational and environmental health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Exposure Assessment and Monitoring of Antiblastic Drugs Preparation in Health Care Settings: A Systematic Review.La Medicina del lavoro · 2024Pooled it
- Systematic review of genotoxicity induced by occupational exposure to antineoplastic drugs.Archives of toxicology · 2023Pooled it
- Closed-system drug-transfer devices plus safe handling of hazardous drugs versus safe handling alone for reducing exposure to infusional hazardous drugs in healthcare staff.The Cochrane database of systematic reviews · 2018Pooled it
- Meta-analysis of chromosomal aberrations as a biomarker of exposure in healthcare workers occupationally exposed to antineoplastic drugs.Mutation research. Reviews in mutation researchPooled it
- Administering Antineoplastic Parenteral Cancer Therapy in the Patient's Home: Perspectives of Oncology Nurses-A Descriptive Qualitative Study.Nursing open · 2026Article
- Cytotoxic Drug Handling Practices Among Pharmacy Technicians in Portugal: The Dig Deeper Study.Healthcare (Basel, Switzerland) · 2026Article
- Health Effects of Ergonomics and Personal Protective Equipment on Chemotherapy Professionals.Current oncology (Toronto, Ont.) · 2025Review
- Side-by-Side Comparison of Methods for Environmental Monitoring for Hazardous Drug Contamination.The Canadian journal of hospital pharmacy · 2023Article
- External contamination of antineoplastic drug vials: an occupational risk to consider.European journal of hospital pharmacy : science and practice · 2022Article
- The Oxidative Stress Parameters as Useful Tools in Evaluating the DNA Damage and Changes in the Complete Blood Count in Hospital Workers Exposed to Low Doses of Antineoplastic Drugs and Ionizing Radiation.International journal of environmental research and public health · 2021Article
- Genotoxic evaluation of occupational exposure to antineoplastic drugs.Toxicological research · 2020Article
- Article
- Occupational exposure to chemical substances and health outcomes among hospital environmental services workers: A scoping review of international studies.Journal of occupational and environmental hygieneArticle
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesRecently published works showed that occupational exposure to antineoplastic drugs (ANPD) is still frequent in hospital settings, despite significant safety policy improvements. The aim of this study was to assess the current level of occupational exposure to ANPD and any potentially associated cytogenetic damages in hospital nurses routinely handling ANPD.
methodsOccupationally ANPD-exposed (n = 71) and ANPD-unexposed (n = 77; control) nurses were recruited on a voluntary basis from five hospitals in Northern and Central Italy. Evaluation of surface contamination and dermal exposure to ANPD was assessed by determining cyclophosphamide (CP) on selected surfaces (wipes) and on exposed nurses' clothes (pads). The concentration of unmetabolized CP—as a biomarker of internal dose—was measured in end-shift urine samples. Biomonitoring of genotoxic effects (i.e., biological effect monitoring) was conducted by analyzing micronuclei (MN) and chromosome aberrations (CA) in peripheral blood lymphocytes. Genetic polymorphisms for enzymes involved in metabolic detoxification (i.e., glutathione S-transferases) were analyzed as well.
resultsWe observed a significant increase in MN frequency (5.30 ± 2.99 and 3.29 ± 1.97; mean values ± standard deviation; p < 0.0001) in exposed nurses versus controls, as well as in CA detection (3.30 ± 2.05 and 1.84 ± 1.67; p < 0.0001), exposed subjects versus controls. Our results provide evidence that, despite safety controlled conditions, ANPD handling still represents a considerable genotoxic risk for occupationally exposed personnel.
conclusionsBecause both MN and CA have been described as being predictive of group-increased cancer risk, our findings point to a need for improving specific safety procedures in handling and administering ANPD.
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