ArticleDigestive diseases and sciences2015
BPTF Associated with EMT Indicates Negative Prognosis in Patients with Hepatocellular Carcinoma.
Article in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Single-cell eQTL mapping reveals cell-type-specific genetic regulation in lung cancer.Cell genomics · 2026Article
- BPTF Target Engagement by Acetylated H2A.Z Photoaffinity Probes.Biochemistry · 2025Article
- Targeting regulation of VEGF by BPTF in non-small cell lung cancer and its potential clinical significance.European journal of medical research · 2022Article
- BPTF promotes the progression of distinct subtypes of breast cancer and is a therapeutic target.Frontiers in oncology · 2022Article
- KIAA1429 regulates alternative splicing events of cancer-related genes in hepatocellular carcinoma.Frontiers in oncology · 2022Article
- Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF.Current opinion in chemical biology · 2021Review
- New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development.Organic & biomolecular chemistry · 2020Article
- NMR Analyses of Acetylated H2A.Z Isoforms Identify Differential Binding Interactions with the Bromodomain of the NURF Nucleosome Remodeling Complex.Biochemistry · 2020Article
- BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway.Oncogene · 2020Article
- Unresolved Complexity in the Gene Regulatory Network Underlying EMT.Frontiers in oncology · 2020Review
- SAR by (Protein-Observed)Accounts of chemical research · 2019Review
- Selectivity, ligand deconstruction, and cellular activity analysis of a BPTF bromodomain inhibitor.Organic & biomolecular chemistry · 2019Article
- Bromodomain PHD‑finger transcription factor promotes glioma progression and indicates poor prognosis.Oncology reports · 2019Article
- BPTF promotes hepatocellular carcinoma growth by modulating hTERT signaling and cancer stem cell traits.Redox biology · 2019Article
- Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis.International journal of molecular sciences · 2018Review
- Whole exome sequencing reveals novel somatic alterations in neuroblastoma patients with chemotherapy.Cancer cell international · 2018Article
- Haploinsufficiency of the Chromatin Remodeler BPTF Causes Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features.American journal of human genetics · 2017Article
- DDR2 Induces Gastric Cancer Cell Activities via Activating mTORC2 Signaling and Is Associated with Clinicopathological Characteristics of Gastric Cancer.Digestive diseases and sciences · 2016Article
- Article
- The prognostic significance of bromodomain PHD-finger transcription factor in colorectal carcinoma and association with vimentin and E-cadherin.Journal of cancer research and clinical oncology · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsEpithelial-mesenchymal transition (EMT) plays an important role in hepatocellular carcinoma (HCC) dissemination. Bromodomain PHD-finger transcription factor (BPTF) could regulate embrogenesis and stem cell differentiation, and it may be involved in tumor progression and EMT. In this study, we aimed to determine BPTF, E-cadherin and vimentin expression in tumor tissues and the clinical significance in relation to HCC.
methodsThe BPTF, vimentin and E-cadherin expression of 106 HCC tissue samples was examined by immunohistochemical staining.
resultsBPTF and vimentin showed high expression and E-cadherin showed low expression in HCC. BPTF is associated with the tumor number, vascular invasion, Edmondson-Steiner grade, TNM stage and recurrence (P < 0.05). Vimentin is positively correlated with tumor size, tumor number, vascular invasion, Edmondson-Steiner grade, TNM stage and recurrence (P < 0.05). E-cadherin is negatively correlated with tumor number, Edmondson-Steiner grade, TNM stage and recurrence (P < 0.05). Survival analysis has shown that high expression of BPTF and vimentin indicates poorer overall and disease-free survival (P < 0.05). Multivariate analysis shows that BPTF is an independent marker for survival prediction (P = 0.015). Additionally, high BPTF expression is correlated with high vimentin expression and low E-cadherin expression (P < 0.05).
conclusionHigh BPTF expression may be an independent marker for survival prediction in HCC patients and is probably involved in EMT.
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