ArticleDrug safety2014
Multiple drug intolerance syndrome: a large-scale retrospective study.
Article in Drug safety, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Multiple Drug Intolerance Syndrome and Arterial Hypertension-Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Risk factors, clinical presentations, and common culprits in drug allergies: a case-control study from Türkiye.Postepy dermatologii i alergologii · 2025Article
- Bridging the Gender Gap in Cardiovascular Medicine: Addressing Drug Intolerances and Personalized Care for Women with Angina/Ischemia with Non-Obstructive Coronary Artery Disease.Journal of cardiovascular development and disease · 2024Review
- Onabotulinum toxin a treatment for posttraumatic trigeminal neuropathic pain: case series and literature review.Journal of oral & facial pain and headache · 2024Review
- Delabelling multiple antibiotic allergy: Practical issues.Frontiers in allergy · 2023Review
- Characterization, epidemiology and risk factors of multiple drug allergy syndrome and multiple drug intolerance syndrome: A systematic review.Clinical and translational allergy · 2022Article
- Population-Based Incidence, Severity, and Risk Factors Associated with Treated Acute-Onset COVID-19 mRNA Vaccination-Associated Hypersensitivity Reactions.The journal of allergy and clinical immunology. In practice · 2022Article
- Validation of a Brief Screening Instrument for Chemical Intolerance in a Large U.S. National Sample.International journal of environmental research and public health · 2021Article
- Psychological profiles of patients with suspected drug allergy.Asia Pacific allergy · 2020Article
- Patient-Reported Allergies, a Marker of Preoperative Pain and Disability in Elective Spine Surgery.Global spine journal · 2020Article
- Article
- Multiple Drug Intolerance Syndrome: An Underreported Distinct Clinical Entity.Current clinical pharmacology · 2019Review
- Article
- Multiple adverse drug reactions and genetic polymorphism testing: A case report with negative result.Medicine · 2017Article
- Shoulder Arthroplasty Outcomes in Patients With Multiple Reported Drug Allergies: Does Number of Drug Allergies Have an Effect on Outcome?Orthopaedic journal of sports medicine · 2016Article
- Management of Hypertensive Patients With Multiple Drug Intolerances: A Single-Center Experience of a Novel Treatment Algorithm.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Adverse Drug Reactions and Clinical Outcomes in Patients Initiated on Antiretroviral Therapy: A Prospective Cohort Study From Ethiopia.Drug safety · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe term multiple drug intolerance syndrome (MDIS) has been used to describe patients who express adverse drug reactions to three or more drugs without a known immunological mechanism.
objectiveTo identify patient factors that could increase the risk of MDIS.
methodInpatient records over a 5-year period were captured from an electronic prescribing system to identify patients with at least one documented drug allergy. Univariable and multivariable analyses were used to compare the rates of MDIS across age, sex, weight, ethnicity, history of atopy or psychological disorders, and previous admissions.
resultsA total of 25,695 patients had a documented drug intolerance, 4.9% of whom had MDIS. MDIS was significantly more likely in women (p < 0.001), patients with multiple comorbidities (p < 0.001), and patients with previous hospital admissions (p < 0.001). With the exception of penicillin (p = 0.749), MDIS was more frequent in those with allergies to other drugs (p < 0.001).
conclusionMDIS was associated with female gender, multiple comorbidities, and previous hospital admissions. A documented allergy to penicillin did not increase the likelihood of MDIS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.