ArticleNature cell biology2014
Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate.
Article in Nature cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Neuroendocrine cells signal for repair: hedgehog leading the way.Signal transduction and targeted therapy · 2025Article
- Article
- Individual and Combined Effect of Bisphenol A and Bisphenol AF on Prostate Cell Proliferation through NF-κB Signaling Pathway.International journal of molecular sciences · 2022Article
- Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer.Cells · 2022Review
- Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Misactivation of Hedgehog signaling causes inherited and sporadic cancers.The Journal of clinical investigation · 2019Review
- Sonic hedgehog signaling in epithelial tissue development.Regenerative medicine research · 2019Article
- Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.The Journal of clinical investigation · 2018Article
- Stromal Gli signaling regulates the activity and differentiation of prostate stem and progenitor cells.The Journal of biological chemistry · 2018Article
- Reproductive, Physiological, and Molecular Outcomes in Female Mice Deficient in Dhh and Ihh.Endocrinology · 2018Article
- Deconstructing the principles of ductal network formation in the pancreas.PLoS biology · 2018Article
- Potential protective effect of ALDH-1 stromal expression against early recurrence of operable breast cancers.Stem cell investigation · 2018Article
- The Stromal Niche for Epithelial Stem Cells: A Template for Regeneration and a Brake on Malignancy.Cancer cell · 2017Review
- Prostate organogenesis: tissue induction, hormonal regulation and cell type specification.Development (Cambridge, England) · 2017Review
- Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer.Disease models & mechanisms · 2017Article
- Hedgehog Signaling in Prostate Development, Regeneration and Cancer.Journal of developmental biology · 2016Review
- miR-26a desensitizes non-small cell lung cancer cells to tyrosine kinase inhibitors by targeting PTPN13.Oncotarget · 2016Article
- Hedgehog pathway maintains cell survival under stress conditions, and drives drug resistance in lung adenocarcinoma.Oncotarget · 2016Article
- Conserved miR-26b enhances ovarian granulosa cell apoptosis through HAS2-HA-CD44-Caspase-3 pathway by targeting HAS2.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Branching morphogenesis is thought to be governed by epithelial-stromal interactions, but the mechanisms underlying specification of branch location remain largely unknown. Prompted by the striking absence of Hedgehog (Hh) response at the sites of nascent buds in regenerating tubules of the adult prostate, we investigated the role of Hh signalling in adult prostate branching morphogenesis. We find that pathway activity is localized to stromal cells, and that its attenuation by genetic or pharmacologic manipulation leads to increased branching. Decreased pathway activity correlates with increased stromal production of hepatocyte growth factor (Hgf), and we show that Hgf induces epithelial tubule branching. Regulation of Hgf expression by Hh signalling is indirect, mediated by Hh-induced expression of the microRNAs miR-26a and miR-26b, which in turn downregulate expression of Hgf. Prostate tubule branching thus may be initiated from regions of low Hh pathway activity, with implications for the prostatic hyperplasia commonly observed in late adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.