ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2014
Structural contributions to fibrillatory rotors in a patient-derived computational model of the atria.
Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 66 citations in OpenAlex.
- Impact of effective refractory period personalization on arrhythmia vulnerability in patient-specific atrial computer models.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation.Physiological reviews · 2024Review
- Systematic in-silico evaluation of fibrosis effects on re-entrant wave dynamics in atrial tissue.Scientific reports · 2024Article
- Organization of atrial fibrillation using a pure sodium channel blocker: Implications of rotor ablation therapy.Journal of arrhythmia · 2023Article
- Fiber Organization Has Little Effect on Electrical Activation Patterns During Focal Arrhythmias in the Left Atrium.IEEE transactions on bio-medical engineering · 2023Article
- Article
- Forward-Solution Noninvasive Computational Arrhythmia Mapping: The VMAP Study.Circulation. Arrhythmia and electrophysiology · 2022Article
- Left atrial evaluation by cardiovascular magnetic resonance: sensitive and unique biomarkers.European heart journal. Cardiovascular Imaging · 2021Article
- Mapping atrial fibrillation : An overview of potential mechanisms underlying atrial fibrillation.Herz · 2021Review
- Association of low-voltage areas with the regional wall deformation and the left atrial shape in patients with atrial fibrillation: A proof of concept study.International journal of cardiology. Heart & vasculature · 2021Article
- Ventricular fibrillation mechanism and global fibrillatory organization are determined by gap junction coupling and fibrosis pattern.Cardiovascular research · 2021Article
- Unmasking Arrhythmogenic Hubs of Reentry Driving Persistent Atrial Fibrillation for Patient-Specific Treatment.Journal of the American Heart Association · 2020Article
- Identifying locations of re-entrant drivers from patient-specific distribution of fibrosis in the left atrium.PLoS computational biology · 2020Article
- Linking Electrical Drivers With Atrial Cardiomyopathy for the Targeted Treatment of Atrial Fibrillation.Frontiers in physiology · 2020Review
- Mechanisms by Which Ranolazine Terminates Paroxysmal but Not Persistent Atrial Fibrillation.Circulation. Arrhythmia and electrophysiology · 2019Article
- Atrial Fibrosis: Translational Considerations for the Management of AF Patients.Arrhythmia & electrophysiology review · 2019Review
- Understanding the Beat-to-Beat Variations of P-Waves Morphologies in AF Patients During Sinus Rhythm: A Scoping Review of the Atrial Simulation Studies.Frontiers in physiology · 2019Article
- Structural remodeling and conduction velocity dynamics in the human left atrium: Relationship with reentrant mechanisms sustaining atrial fibrillation.Heart rhythm · 2019Article
- Dynamical anchoring of distant arrhythmia sources by fibrotic regions via restructuring of the activation pattern.PLoS computational biology · 2018Article
- A new algorithm to visualize the individual relationship between electrical rotors from non-invasive panoramic mapping and atrial fibrosis to guide ablation of persistent atrial fibrillation.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
aimsThe aim of this study was to investigate structural contributions to the maintenance of rotors in human atrial fibrillation (AF) and possible mechanisms of termination. METHODS AND
resultsA three-dimensional human biatrial finite element model based on patient-derived computed tomography and arrhythmia observed at electrophysiology study was used to study AF. With normal physiological electrical conductivity and effective refractory periods (ERPs), wave break failed to sustain reentrant activity or electrical rotors. With depressed excitability, decreased conduction anisotropy, and shorter ERP characteristic of AF, reentrant rotors were readily maintained. Rotors were transiently or permanently trapped by fibre discontinuities on the lateral wall of the right atrium near the tricuspid valve orifice and adjacent to the crista terminalis, both known sites of right atrial arrhythmias. Modelling inexcitable regions near the rotor tip to simulate fibrosis anchored the rotors, converting the arrhythmia to macro-reentry. Accordingly, increasing the spatial core of inexcitable tissue decreased the frequency of rotation, widened the excitable gap, and enabled an external wave to impinge on the rotor core and displace the source.
conclusionThese model findings highlight the importance of structural features in rotor dynamics and suggest that regions of fibrosis may anchor fibrillatory rotors. Increasing extent of fibrosis and scar may eventually convert fibrillation to excitable gap reentry. Such macro-reentry can then be eliminated by extending the obstacle or by external stimuli that penetrate the excitable gap.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.