ArticleProceedings of the National Academy of Sciences of the United States of America2014
Intracellular metabolite levels shape sulfur isotope fractionation during microbial sulfate respiration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 244 citations in OpenAlex.
- Abundance-activity decoupling in sulfur-cycling bacteria reflects viral infection types in meromictic lakes.The ISME journal · 2026Article
- Sedimentary conditions drive modern pyrite burial flux to exceed oxidation.Nature geoscience · 2026Article
- Molecular insights into the dynamic relationship between respiration rate and sulfur isotope effect.Applied and environmental microbiology · 2025Article
- The barite record of the past seawater oxygen isotope composition.Nature communications · 2025Article
- Nitrogen stable isotope fractionation by biological nitrogen fixation reveals cellular nitrogenase is diffusion limited.PNAS nexus · 2025Article
- Sulfur isotope anomalies in coal combustion: Applications to the present and early Earth environments.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Stable isotopic signature of dissimilatory nitrate reduction is robust against enzyme mutation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Deglacial volcanism and reoxygenation in the aftermath of the Sturtian Snowball Earth.Science advances · 2023Article
- Sulfate triple-oxygen-isotope evidence confirming oceanic oxygenation 570 million years ago.Nature communications · 2023Article
- Recent Advances in Biotechnologies for the Treatment of Environmental Pollutants Based on Reactive Sulfur Species.Antioxidants (Basel, Switzerland) · 2023Review
- What Controls the Sulfur Isotope Fractionation during Dissimilatory Sulfate Reduction?ACS environmental Au · 2023Review
- Electro-polarization of protein-like substances accelerates trans-cell-wall electron transfer in microbial extracellular respiration.iScience · 2023Article
- A Cristae-Like Microcompartment inmBio · 2022Article
- Novel sulfur isotope analyses constrain sulfurized porewater fluxes as a minor component of marine dissolved organic matter.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A transient peak in marine sulfate after the 635-Ma snowball Earth.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Controls on the isotopic composition of microbial methane.Science advances · 2022Article
- Sedimentary pyrite sulfur isotopes track the local dynamics of the Peruvian oxygen minimum zone.Nature communications · 2021Article
- Mass-Transfer-Limited Biodegradation at Low Concentrations-Evidence from Reactive Transport Modeling of Isotope Profiles in a Bench-Scale Aquifer.Environmental science & technology · 2021Article
- Physiological, genomic, and sulfur isotopic characterization of methanol metabolism by Desulfovibrio carbinolicus.PloS one · 2021Article
- Expanded Genomic Sampling Refines Current Understanding of the Distribution and Evolution of Sulfur Metabolisms in theFrontiers in microbiology · 2021Article
Corrections and comments
- Commented on by
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a quantitative model for sulfur isotope fractionation accompanying bacterial and archaeal dissimilatory sulfate respiration. By incorporating independently available biochemical data, the model can reproduce a large number of recent experimental fractionation measurements with only three free parameters: (i) the sulfur isotope selectivity of sulfate uptake into the cytoplasm, (ii) the ratio of reduced to oxidized electron carriers supporting the respiration pathway, and (iii) the ratio of in vitro to in vivo levels of respiratory enzyme activity. Fractionation is influenced by all steps in the dissimilatory pathway, which means that environmental sulfate and sulfide levels control sulfur isotope fractionation through the proximate influence of intracellular metabolites. Although sulfur isotope fractionation is a phenotypic trait that appears to be strain specific, we show that it converges on near-thermodynamic behavior, even at micromolar sulfate levels, as long as intracellular sulfate reduction rates are low enough (<<1 fmol H2S⋅cell(-1)⋅d(-1)).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.