ArticleThe Plant cell2014
Evening expression of arabidopsis GIGANTEA is controlled by combinatorial interactions among evolutionarily conserved regulatory motifs.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Circadian oscillations in chromatin accessibility systematically orchestrate rhythmic gene transcription in soybean.The Plant cell · 2026Article
- Transcriptomic profiling and oxidative stress responses of Catharanthus roseus under short-term LED light exposure.BMC plant biology · 2025Article
- GIGANTEA supresses wilt disease resistance by down-regulating the jasmonate signaling inFrontiers in plant science · 2023Article
- In Silico Characterization and Expression Analysis of GIGANTEA Genes in Potato.Biochemical genetics · 2022Article
- GIpred: a computational tool for prediction of GIGANTEA proteins using machine learning algorithm.Physiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- Photoperiod Control of Plant Growth: Flowering Time Genes Beyond Flowering.Frontiers in plant science · 2021Review
- Multi-level Modulation of Light Signaling by GIGANTEA Regulates Both the Output and Pace of the Circadian Clock.Developmental cell · 2019Article
- HOS15 Interacts with the Histone Deacetylase HDA9 and the Evening Complex to Epigenetically Regulate the Floral ActivatorThe Plant cell · 2019Article
- Early evolution of the land plant circadian clock.The New phytologist · 2017Article
- The transcriptional repressor complex FRS7-FRS12 regulates flowering time and growth in Arabidopsis.Nature communications · 2017Article
- Transcriptomic analysis of differentially expressed genes in the floral transition of the summer flowering chrysanthemum.BMC genomics · 2016Article
- Direct Repression of Evening Genes by CIRCADIAN CLOCK-ASSOCIATED1 in the Arabidopsis Circadian Clock.The Plant cell · 2016Article
- Linked circadian outputs control elongation growth and flowering in response to photoperiod and temperature.Molecular systems biology · 2015Article
- Decoding complexity: tackling the challenge of how many transcription factors regulate a plant gene.TranscriptionReview
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Diurnal patterns of gene transcription are often conferred by complex interactions between circadian clock control and acute responses to environmental cues. Arabidopsis thaliana GIGANTEA (GI) contributes to photoperiodic flowering, circadian clock control, and photoreceptor signaling, and its transcription is regulated by the circadian clock and light. We used phylogenetic shadowing to identify three evolutionarily constrained regions (conserved regulatory modules [CRMs]) within the GI promoter and show that CRM2 is sufficient to confer a similar transcriptional pattern as the full-length promoter. Dissection of CRM2 showed that one subfragment (CRM2-A) contributes light inducibility, while another (CRM2-B) exhibits a diurnal response. Mutational analysis showed that three ABA RESPONSE ELEMENT LIKE (ABREL) motifs in CRM2-A and three EVENING ELEMENTs (EEs) in CRM2-B are essential in combination to confer a high amplitude diurnal pattern of expression. Genome-wide analysis identified characteristic spacing patterns of EEs and 71 A. thaliana promoters containing three EEs. Among these promoters, that of FLAVIN BINDING KELCH REPEAT F-BOX1 was analyzed in detail and shown to harbor a CRM functionally related to GI CRM2. Thus, combinatorial interactions among EEs and ABRELs confer diurnal patterns of transcription via an evolutionarily conserved module present in GI and other evening-expressed genes.
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