ArticleGenetics2015
A general unified framework to assess the sampling variance of heritability estimates using pedigree or marker-based relationships.
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Influence of heritability on occlusal traits: a systematic review of studies in twins.Progress in orthodontics · 2020Pooled it
- Meta-analysis of genome-wide association from genomic prediction models.Animal genetics · 2016Pooled it
- Genetic Parameter Estimation and Breeding Value Ranking for Litter Size Traits in Meat Rabbits: REML and Bayesian Inference Under Limited Data Conditions.Animals : an open access journal from MDPI · 2026Article
- The Heritability of Migration Behaviors in a Wide-Ranging Ungulate.Ecology and evolution · 2026Article
- Modeling production curves in a strawberry breeding program to optimize early season productivity.Frontiers in plant science · 2026Article
- Needle- and Canopy-Level Genetic Variation in Scots Pine (Evolutionary applications · 2025Article
- Transcripts with high distal heritability mediate genetic effects on complex metabolic traits.Nature communications · 2025Article
- Ecological and evolutionary drivers of phenotypic and genetic variation in the European crabapple [Malus sylvestris (L.) Mill.], a wild relative of the cultivated apple.Annals of botany · 2023Article
- A statistical genetic investigation of psychiatric resilience.European journal of psychotraumatology · 2023Article
- Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals.American journal of human genetics · 2021Article
- MRI-visible dilated perivascular spaces in healthy young adults: A twin heritability study.Human brain mapping · 2020Article
- How does contemporary selection shape oak phenotypes?Evolutionary applications · 2020Article
- Identification of genetic loci associated with higher resistance to pancreas disease (PD) in Atlantic salmon (Salmo salar L.).BMC genomics · 2020Article
- Article
- Article
- Exploring the Link Between Additive Heritability and Prediction Accuracy From a Ridge Regression Perspective.Frontiers in genetics · 2020Article
- Article
- Gut microbiome beats two to zero host genome.Hepatobiliary surgery and nutrition · 2019Article
- On Using Local Ancestry to Characterize the Genetic Architecture of Human Traits: Genetic Regulation of Gene Expression in Multiethnic or Admixed Populations.American journal of human genetics · 2019Article
- Realized Genome Sharing in Heritability Estimation Using Random Effects Models.G3 (Bethesda, Md.) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Heritability is a population parameter of importance in evolution, plant and animal breeding, and human medical genetics. It can be estimated using pedigree designs and, more recently, using relationships estimated from markers. We derive the sampling variance of the estimate of heritability for a wide range of experimental designs, assuming that estimation is by maximum likelihood and that the resemblance between relatives is solely due to additive genetic variation. We show that well-known results for balanced designs are special cases of a more general unified framework. For pedigree designs, the sampling variance is inversely proportional to the variance of relationship in the pedigree and it is proportional to 1/N, whereas for population samples it is approximately proportional to 1/N(2), where N is the sample size. Variation in relatedness is a key parameter in the quantification of the sampling variance of heritability. Consequently, the sampling variance is high for populations with large recent effective population size (e.g., humans) because this causes low variation in relationship. However, even using human population samples, low sampling variance is possible with high N.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.