Evidence map›Paper›PMID 25361785›Full record

Trial reportNeurology2014

Improving functional disability and cognition in Parkinson disease: randomized controlled trial.

Javier Peña, Naroa Ibarretxe-Bilbao, Inés García-Gorostiaga, Maria Angeles Gomez-Beldarrain, María Díez-Cirarda, Natalia Ojeda

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02118480 (Improving Functional Disability and Cognition in Parkinson Disease), which is not on this map. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02118480 nacompletednot on this map

Improving Functional Disability and Cognition in Parkinson Disease: Randomized Controlled Trial

TypeinterventionalSponsorUniversity of DeustoRan2012 to 2013Enrolled44ConditionsPARKINSON DISEASE (Disorder)Armscognitive remediation program: REHACOP, Occupational Therapy
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Effects of cognitive rehabilitation in Parkinson disease: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Review
  12. Review
  13. Cognition and Activity of Daily Living Function in people with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Javier PeñaFrom the Department of Methods and Experimental Psychology (J.P., N.I.-B., M.D.-C., N.O.), Faculty of Psychology and Education, University of Deusto, Bilbao, Basque Country; and Department of Neurology (I.G.-G., M.A.G.-B.), Galdakao Hospital, Basque Country, Spain.
Naroa Ibarretxe-BilbaoFrom the Department of Methods and Experimental Psychology (J.P., N.I.-B., M.D.-C., N.O.), Faculty of Psychology and Education, University of Deusto, Bilbao, Basque Country; and Department of Neurology (I.G.-G., M.A.G.-B.), Galdakao Hospital, Basque Country, Spain. naroa.ibarretxe@deusto.es.
Inés García-GorostiagaFrom the Department of Methods and Experimental Psychology (J.P., N.I.-B., M.D.-C., N.O.), Faculty of Psychology and Education, University of Deusto, Bilbao, Basque Country; and Department of Neurology (I.G.-G., M.A.G.-B.), Galdakao Hospital, Basque Country, Spain.
Maria Angeles Gomez-BeldarrainFrom the Department of Methods and Experimental Psychology (J.P., N.I.-B., M.D.-C., N.O.), Faculty of Psychology and Education, University of Deusto, Bilbao, Basque Country; and Department of Neurology (I.G.-G., M.A.G.-B.), Galdakao Hospital, Basque Country, Spain.
María Díez-CirardaFrom the Department of Methods and Experimental Psychology (J.P., N.I.-B., M.D.-C., N.O.), Faculty of Psychology and Education, University of Deusto, Bilbao, Basque Country; and Department of Neurology (I.G.-G., M.A.G.-B.), Galdakao Hospital, Basque Country, Spain.
Natalia OjedaFrom the Department of Methods and Experimental Psychology (J.P., N.I.-B., M.D.-C., N.O.), Faculty of Psychology and Education, University of Deusto, Bilbao, Basque Country; and Department of Neurology (I.G.-G., M.A.G.-B.), Galdakao Hospital, Basque Country, Spain.
Hospital de Galdakao · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo examine the efficacy of an integrative cognitive training program (REHACOP) to improve cognition, clinical symptoms, and functional disability of patients with Parkinson disease (PD).

methodsForty-two patients diagnosed with PD in Hoehn & Yahr stages 1 to 3 were randomly assigned to either the cognitive training group (REHACOP) or the control group (occupational activities) for 3 months (3 sessions, 60 min/wk). Primary outcomes were change on processing speed, verbal memory, visual memory, executive functioning, and theory of mind. Secondary outcomes included changes on neuropsychiatric symptoms, depression, apathy, and functional disability. The trial was registered with clinicaltrials.gov (NCT02118480).

resultsNo baseline group differences were found. Bootstrapped analysis of variance results showed significant differences in the mean change scores between the REHACOP group and control group in processing speed (0.13 [SE = 0.07] vs -0.15 [SE = 0.09], p = 0.025), visual memory (0.10 [SE = 0.10] vs -0.24 [SE = 0.09], p = 0.011), theory of mind (1.00 [SE = 0.37] vs -0.27 [SE = 0.29], p = 0.013), and functional disability (-5.15 [SE = 1.35] vs 0.53 [SE = 1.49], p = 0.012).

conclusionsPatients with PD receiving cognitive training with REHACOP demonstrated statistically significant and clinically meaningful changes in processing speed, visual memory, theory of mind, and functional disability. Future studies should consider the long-term effect of this type of intervention. These findings support the integration of cognitive training into the standard of care for patients with PD. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that for patients with PD, an integrative cognitive training program improves processing speed, visual memory, theory of mind, and functional disability.

Indexed as

Cognitive Behavioral TherapyAgedCognition DisordersExecutive FunctionFemaleHumansMaleMemoryNeuropsychological TestsParkinson DiseaseTreatment Outcome

Identifiers

PMID25361785
PMCPMC4276404
OpenAlexW2142721931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.