Trial reportCirculation2015
Familial clustering of mitral valve prolapse in the community.
Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Circulation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 73 citations in OpenAlex.
- Changing trends in burden of calcific aortic valve diseases and degenerative mitral valve diseases among people aged 60-89 years from 1990 to 2030.European journal of medical research · 2025Article
- Mitral Valve Prolapse and Sudden Cardiac Death-A Puzzle with Missing Pieces: Review of the Literature and Case Report.Medical sciences (Basel, Switzerland) · 2025Review
- AClinical case reports · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Inheritance of Imaging Parameters of Arrhythmic Risk in Mitral Valve Prolapse: A Pedigree Study.Circulation. Cardiovascular imaging · 2025Article
- Imaging for the assessment of the arrhythmogenic potential of mitral valve prolapse.European radiology · 2024Review
- Insights into the Inherited Basis of Valvular Heart Disease.Current cardiology reports · 2024Review
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Arrhythmogenic Mitral Valve Prolapse: Can We Risk Stratify and Prevent Sudden Cardiac Death?Arrhythmia & electrophysiology review · 2024Review
- Genetic mechanisms underlying arrhythmogenic mitral valve prolapse: Current and future perspectives.Heart rhythm O2 · 2023Review
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- Biology of mitral valve prolapse: from general mechanisms to advanced molecular patterns-a narrative review.Frontiers in cardiovascular medicine · 2023Review
- Genetics and pathophysiology of mitral valve prolapse.Frontiers in cardiovascular medicine · 2023Review
- EHRA expert consensus statement on arrhythmic mitral valve prolapse and mitral annular disjunction complex in collaboration with the ESC Council on valvular heart disease and the European Association of Cardiovascular Imaging endorsed cby the Heart Rhythm Society, by the Asia Pacific Heart Rhythm Society, and by the Latin American Heart Rhythm Society.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022Article
- Article
- Valvular disease burden in the modern era of percutaneous and surgical interventions: the UK Biobank.Open heart · 2022Article
- Developing a Mechanistic Approach to Sudden Death Prevention in Mitral Valve Prolapse.Journal of clinical medicine · 2022Review
- Global epidemiology of valvular heart disease.Nature reviews. Cardiology · 2021Review
- Hidden in Plain Sight: A Case of Arrhythmic Mitral Valve Prolapse Presenting as Cardiac Arrest.Cureus · 2021Article
- Prevalence and potential genetic determinants of young sudden unexplained death victims with suspected arrhythmogenic mitral valve prolapse syndrome.Heart rhythm O2 · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Francesca N DellingFrom Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA; Section of Mathematics and Statistics, Boston University, Boston, MA (M.G.L.); and Center for Human Genetic Research (S.A.S.) and Cardiac Ultrasound Laboratory, Department of Medicine (R.A.L.), Massachusetts General Hospital, Harvard Medical School, Boston. fdelling@bidmc.harvard.edu.
Jian RongFrom Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA; Section of Mathematics and Statistics, Boston University, Boston, MA (M.G.L.); and Center for Human Genetic Research (S.A.S.) and Cardiac Ultrasound Laboratory, Department of Medicine (R.A.L.), Massachusetts General Hospital, Harvard Medical School, Boston.
Martin G LarsonFrom Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA; Section of Mathematics and Statistics, Boston University, Boston, MA (M.G.L.); and Center for Human Genetic Research (S.A.S.) and Cardiac Ultrasound Laboratory, Department of Medicine (R.A.L.), Massachusetts General Hospital, Harvard Medical School, Boston.
Birgitta LehmanFrom Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA; Section of Mathematics and Statistics, Boston University, Boston, MA (M.G.L.); and Center for Human Genetic Research (S.A.S.) and Cardiac Ultrasound Laboratory, Department of Medicine (R.A.L.), Massachusetts General Hospital, Harvard Medical School, Boston.
Ewa OsypiukFrom Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA; Section of Mathematics and Statistics, Boston University, Boston, MA (M.G.L.); and Center for Human Genetic Research (S.A.S.) and Cardiac Ultrasound Laboratory, Department of Medicine (R.A.L.), Massachusetts General Hospital, Harvard Medical School, Boston.
Plamen StantchevFrom Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA; Section of Mathematics and Statistics, Boston University, Boston, MA (M.G.L.); and Center for Human Genetic Research (S.A.S.) and Cardiac Ultrasound Laboratory, Department of Medicine (R.A.L.), Massachusetts General Hospital, Harvard Medical School, Boston.
Susan A SlaugenhauptFrom Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA; Section of Mathematics and Statistics, Boston University, Boston, MA (M.G.L.); and Center for Human Genetic Research (S.A.S.) and Cardiac Ultrasound Laboratory, Department of Medicine (R.A.L.), Massachusetts General Hospital, Harvard Medical School, Boston.
Emelia J BenjaminFrom Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA; Section of Mathematics and Statistics, Boston University, Boston, MA (M.G.L.); and Center for Human Genetic Research (S.A.S.) and Cardiac Ultrasound Laboratory, Department of Medicine (R.A.L.), Massachusetts General Hospital, Harvard Medical School, Boston.
Robert A LevineFrom Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA; Section of Mathematics and Statistics, Boston University, Boston, MA (M.G.L.); and Center for Human Genetic Research (S.A.S.) and Cardiac Ultrasound Laboratory, Department of Medicine (R.A.L.), Massachusetts General Hospital, Harvard Medical School, Boston.
Ramachandran S VasanFrom Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA; Section of Mathematics and Statistics, Boston University, Boston, MA (M.G.L.); and Center for Human Genetic Research (S.A.S.) and Cardiac Ultrasound Laboratory, Department of Medicine (R.A.L.), Massachusetts General Hospital, Harvard Medical School, Boston.
Boston University · USBeth Israel Deaconess Medical Center · USHarvard University · US
Funding
Ventricular Vascular Coupling: Correlates and PrognosisR01HL080124 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2005 to 2009
$3.4MImproving Mitral Compensation in Ischemic RegurgitationR01HL109506 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI AIKAWA, ELENA, BISCHOFF, JOYCE E. · 2012 to 2015
$3.3MAortic Dysfunction, Pulsatile Stress and Target Organ Damage in FraminghamR01HL107385 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MITCHELL, GARY FRANK, RAMACHANDRAN, VASAN S · 2011 to 2014
$2.6MGenetic Determinants and Progression of Mitral Valve ProlapseK23HL116652 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DELLING, FRANCESCA N · 2014 to 2018
$699kTHE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–NHLBI NIH HHS K23 HL116652NHLBI NIH HHS K23HL116652NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01-HC-25195NHLBI NIH HHS R01HL0107385NHLBI NIH HHS R01HL080124NHLBI NIH HHS R01 HL107385NHLBI NIH HHS R01 HL109506
Abstract
backgroundKnowledge of mitral valve prolapse (MVP) inheritance is based on pedigree observation and M-mode echocardiography. The extent of familial clustering of MVP among unselected individuals in the community using current, more specific echocardiographic criteria is unknown. In addition, the importance of nondiagnostic MVP morphologies (NDMs; first described in large pedigrees) has not been investigated in the general population. We hypothesized that parental MVP and NDMs increase the risk of offspring MVP. METHODS AND
resultsStudy participants were 3679 Generation 3 individuals with available parental data in the Offspring or the New Offspring Spouse cohorts. MVP and NDMs were distinguished by leaflet displacement >2 versus ≤2 mm beyond the mitral annulus, respectively. We compared MVP prevalence in Generation 3 participants with at least 1 parent with MVP (n=186) with that in individuals without parental MVP (n=3493). Among 3679 participants (53% women; mean age, 40±9 years), 49 (1%) had MVP. Parental MVP was associated with a higher prevalence of MVP in Generation 3 participants (10 of 186, 5.4%) compared with no parental MVP (39 of 3493, 1.1%; adjusted odds ratio, 4.51; 95% confidence interval, 2.13-9.54; P<0.0001). When parental NDMs were examined alone, the prevalence of Generation 3 MVP remained higher (12 of 484, 2.5%) compared with those without parental MVP or NDMs (27 of 3009, 0.9%; adjusted odds ratio, 2.52; 95% confidence interval, 1.25-5.10; P=0.01).
conclusionsParental MVP and NDMs are associated with increased prevalence of offspring MVP, highlighting the genetic substrate of MVP and the potential clinical significance of NDMs in the community.
Indexed as
FamilyResidence CharacteristicsAdultCluster AnalysisCohort StudiesFemaleHumansMaleMiddle AgedMitral Valve Prolapseechocardiographyepidemiologygeneticsmitral valve prolapse
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