ArticlePathology oncology research : POR2015
Notch Signaling Target Genes are Directly Correlated to Esophageal Squamous Cell Carcinoma Tumorigenesis.
Article in Pathology oncology research : POR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Two Cohorts, One Network: Consensus Master Regulators Orchestrating Papillary Thyroid Carcinoma.International journal of molecular sciences · 2025Article
- SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms.Molecular medicine (Cambridge, Mass.) · 2024Review
- Molecular characteristics and multivariate survival analysis of 43 patients with locally advanced or metastatic esophageal squamous cell carcinoma.Journal of thoracic disease · 2024Article
- Integrative network-based approaches identified systems-level molecular signatures associated with gallbladder cancer pathogenesis from gallstone diseases.Journal of biosciences · 2022Article
- An In Vivo Study ofBioMed research international · 2022Article
- Mutational processes in cancer preferentially affect binding of particular transcription factors.Scientific reports · 2021Article
- Reciprocal activation of HEY1 and NOTCH4 under SOX2 control promotes EMT in head and neck squamous cell carcinoma.International journal of oncology · 2021Article
- SOX2/SALL4 stemness axis modulates Notch signaling genes to maintain self-renewal capacity of esophageal squamous cell carcinoma.Molecular and cellular biochemistry · 2021Article
- Genomic Analysis Revealed Mutational Traits Associated with Clinical Outcomes in Osteosarcoma.Cancer management and research · 2021Article
- TWIST1 correlates with Notch signaling pathway to develop esophageal squamous cell carcinoma.Molecular and cellular biochemistry · 2020Article
- Crosstalk between MEIS1 and markers of different cell signaling pathways in esophageal squamous cell carcinoma.Molecular biology reports · 2020Article
- MAML1 promotes ESCC aggressiveness through upregulation of EMT marker TWIST1.Molecular biology reports · 2020Article
- Identification of tumorigenicity-associated genes in osteosarcoma cell lines based on bioinformatic analysis and experimental validation.Journal of Cancer · 2020Article
- Changing expression profiles of lncRNAs, circRNAs and mRNAs in esophageal squamous carcinoma.Oncology letters · 2019Article
- LSD1 regulates Notch and PI3K/Akt/mTOR pathways through binding the promoter regions of Notch target genes in esophageal squamous cell carcinoma.OncoTargets and therapy · 2019Article
- Predicting the Correlation of EZH2 and Cancer Stem Cell Markers in Esophageal Squamous Cell Carcinoma.Journal of gastrointestinal cancer · 2018Article
- Molecular Signaling in Tumorigenesis of Gastric CancerIranian biomedical journal · 2018Review
- TheClinical cancer research : an official journal of the American Association for Cancer Research · 2018Article
- Crosstalk between SHH and stemness state signaling pathways in esophageal squamous cell carcinoma.Journal of cell communication and signaling · 2017Article
- Biological and Clinicopathological Significance of Cripto-1 Expression in the Progression of Human ESCC.Reports of biochemistry & molecular biology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Notch signaling is an important cellular pathway which affects the development and function of many organs. It plays critical roles in maintaining of progenitor stem cell population as well as balancing cell proliferation, survival, differentiation and apoptosis. It has been shown that notch signaling is aberrantly activated during the carcinogenesis of a variety of human cancers. In this study we aimed to explore activation of this signaling pathway in esophageal squamous cell carcinoma (ESCC) through expressional analysis of notch signaling target genes. The mRNA expression of HEY1 and HEY2 was comparatively analyzed by real-time PCR in tumor and related margin normal tissues of 50 ESCC patients. Comparative quantitative real-time PCR indicates the overexpression of HEY1 and HEY2 in 54 and 30% of ESCC samples, respectively. Overexpression of HEY1 was significantly associated with stage of the tumor (p = 0.048) and tumor location (p = 0.008). HEY2 overexpression was also significantly correlated to node metastasis of tumor cells (p = 0.043). Overexpression of HEY1 and HEY2 in ESCC is correlated to different indices of poor prognosis and it is extrapolated that such overexpression is important in progression and development of ESCC tumorigenesis. To the best of our knowledge, this is the first report introducing aberrant activation of notch signaling target genes in ESCC, where it plays roles in development and progression of the malignancy and may be considered in therapeutic modalities to restrict ESCC progression.
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