ArticleCognitive neuroscience2014
Functional connectivity of the posterior hippocampus is more dominant as we age.
Article in Cognitive neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Age-related differences in brain activity despite matched cognitive performance: A moderated-mediation analysis.Brain imaging and behavior · 2026Article
- Structural and functional sex differences in medial temporal lobe subregions at midlife.BMC neuroscience · 2024Article
- Functional connectivity changes of the hippocampal subregions in anti-N-methyl-D-aspartate receptor encephalitis.Brain imaging and behavior · 2024Article
- Pulsatility analysis of the circle of Willis.Aging brain · 2024Article
- Abnormalities of Hippocampal Subfield and Amygdalar Nuclei Volumes and Clinical Correlates in Behavioral Variant Frontotemporal Dementia with Obsessive-Compulsive Behavior-A Pilot Study.Brain sciences · 2023Article
- Alterations in Human Hippocampus Subregions across the Lifespan: Reflections on White Matter Structure and Functional Connectivity.Neural plasticity · 2023Article
- The "vestibular neuromatrix": A proposed, expanded vestibular network from graph theory in post-concussive vestibular dysfunction.Human brain mapping · 2022Article
- Group-guided individual functional parcellation of the hippocampus and application to normal aging.Human brain mapping · 2021Article
- Different posterior hippocampus and default mode network modulation in young APOE ε4 carriers: a functional connectome-informed phenotype longitudinal study.Molecular neurobiology · 2021Article
- Hippocampal functional connectivity development during the first two years indexes 4-year working memory performance.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Age-related alterations in functional connectivity along the longitudinal axis of the hippocampus and its subfields.Hippocampus · 2021Article
- Hippocampus co-atrophy pattern in dementia deviates from covariance patterns across the lifespan.Brain : a journal of neurology · 2020Article
- Effective connectivity during autobiographical memory search.Brain and behavior · 2020Article
- Abnormal resting-state functional connectivity of hippocampal subfields in patients with major depressive disorder.BMC psychiatry · 2020Article
- Neural evidence for age-related differences in representational quality and strategic retrieval processes.Neurobiology of aging · 2019Article
- Differential Functional Connectivity along the Long Axis of the Hippocampus Aligns with Differential Role in Memory Specificity and Generalization.Journal of cognitive neuroscience · 2019Article
- Reality Is in the Posterior Hippocampus: Who Knew?Epilepsy currents · 2019Article
- Region-specific association between basal blood insulin and cerebral glucose metabolism in older adults.NeuroImage. Clinical · 2019Article
- Resting-state functional connectivity of anterior and posterior hippocampus in posttraumatic stress disorder.Journal of psychiatric research · 2017Article
- Distinct Properties of Long-Term Potentiation in the Dentate Gyrus along the Dorsoventral Axis: Influence of Age and Inhibition.Scientific reports · 2017Article
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Authors and funding
5 authors.
Funding
Abstract
The role of the hippocampus in memory is dependent on its interaction with distributed brain areas. Anterior and posterior hippocampus have different roles in memory processing, and are impacted differently by aging in terms of structural decline, however, functional connectivity of these hippocampal regions in aging is not well understood. Young (age 17-30) and aging (age 60-69) cognitively normal subjects underwent resting-state functional MRI revealing a shift from anterior hippocampus dominant hippocampus connectivity in younger age group to posterior hippocampus dominant connectivity in aging subjects. We identified a subset of neocortical regions that are connected to the anterior hippocampus in younger adults but to the posterior hippocampus among older subjects, suggesting an age-related reorganization of hippocampal networks supporting normal cognitive function. We also performed volumetric analysis which revealed no significant structural differences between groups. These findings provide evidence that "functional anatomy" which supports normal memory performance changes across the life span.
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