ArticleMedical science monitor : international medical journal of experimental and clinical research2014
Serum γ-glutamyltransferase level is associated with periodontal disease independent of drinking habits in Japanese adults.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The potential association between periodontitis and non-alcoholic fatty liver disease: a systematic review.Clinical oral investigations · 2018Pooled it
- Porphyromonas gingivalis OMVs Activate Macrophage-Hepatic Stellate Cells via Thbs1/TGF-β Signalling in NAFLD.International dental journal · 2026Article
- The correlation between periodontitis and fatty liver and the improvement of NAFLD by periodontal treatment.Frontiers in oral health · 2026Review
- Potential association between periodontitis and liver function test abnormalities: Results from the National Health and Nutrition Examination Survey (NHANES) 2009-2014.Journal of dental sciences · 2025Article
- Role of Nonalcoholic Fatty Liver Disease in Periodontitis: A Bidirectional Relationship.Cureus · 2024Review
- Associations between Periodontal Status and Liver Function in the Japanese Population: A Cross-Sectional Study.Journal of clinical medicine · 2023Article
- Review
- Periodontal and Hepatic Parameters in Obese Patients Undergoing Bariatric Surgery.Oral health & preventive dentistry · 2022Article
- Relationship between NAFLD and Periodontal Disease from the View of Clinical and Basic Research, and Immunological Response.International journal of molecular sciences · 2021Review
- Association between serum IgG antibody titers againstHeliyon · 2020Article
- Article
- One or two ligatures inducing periodontitis are sufficient to cause fatty liver.Medicina oral, patologia oral y cirugia bucal · 2018Article
- Association of liver enzyme levels and alveolar bone loss: A cross-sectional clinical study in Sado Island.Journal of clinical and experimental dentistry · 2018Article
- Decrease of Pericytes is Associated With Liver Disease Caused by Ligature-Induced Periodontitis in Rats.Journal of periodontology · 2017Article
- Interaction between periodontitis and liver diseases.Biomedical reports · 2016Article
- Interrelationship Between Periapical Lesion and Systemic Metabolic Disorders.Current pharmaceutical design · 2016Review
- Assessment of gingival crevicular fluid levels of gamma glutamyl transferase in chronic periodontitis patients before and after non-surgical periodontal therapy: A clinico-biochemical study.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Non-alcoholic fatty liver disease is considered a hepatic manifestation of metabolic syndrome. Periodontal disease is a mild chronic inflammatory disease with systemic effects, and many studies have indicated an association between metabolic syndrome and periodontitis. In the present study, we investigated the relationship between periodontitis and liver biochemical parameters according to alcohol drinking habits through a cross-sectional study based on data from Japanese people in occupational settings. Material and Methods The subjects were 1510 employees (1218 males, 292 females, mean age 50.4 years) who underwent dental and medical checkups in 2012. Associations between the presence of periodontal pockets and serum levels of liver biochemical parameters were assessed. Results Alanine aminotransferase (ALT) and γ-glutamyltransferase (GGT) levels were higher in subjects with than without periodontal pockets. Multiple logistic regression analysis (adjusting for age, gender, cigarette smoking, and alcohol drinking habits, and components of metabolic syndrome) with GGT or ALT as the dependent variable revealed that there was a significant association between periodontal pockets and GGT (odds ratio, OR=1.48), but not ALT. Similar associations were observed when an analysis was performed according to the presence or absence of alcohol drinking habits; the OR was higher in subjects without (OR=1.84) than with drinking habits (OR=1.41). Conclusions The presence of periodontal pockets was associated with serum levels of GGT, a liver biochemical parameter, in Japanese adults with no drinking habit, suggesting that periodontal disease is associated with liver function, independent of alcohol ingestion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.