Evidence map›Paper›PMID 25360706›Full record

ArticlePloS one2014

Combining use of captopril and losartan attenuates the progress of Streptococcus pneumoniae-induced tympanosclerosis through the suppression of TGF-β1 expression.

Wenqing Yan, Jianfeng Li, Renjie Chai, Wentao Guo, Lei Xu, Yuechen Han, Xiaohui Bai, Haibo Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Wenqing YanDepartment of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, P.R. China; Shandong Institute of Otolaryngology, Jinan, P.R. China.
Jianfeng LiDepartment of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, P.R. China; Shandong Institute of Otolaryngology, Jinan, P.R. China; Shandong Provincial Key Laboratory of Otology, Jinan, P.R. China.
Renjie ChaiKey Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, P.R. China.
Wentao GuoDepartment of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, P.R. China.
Lei XuDepartment of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, P.R. China.
Yuechen HanDepartment of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, P.R. China.
Xiaohui BaiDepartment of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, P.R. China; Shandong Institute of Otolaryngology, Jinan, P.R. China; Shandong Provincial Key Laboratory of Otology, Jinan, P.R. China.
Haibo WangDepartment of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, P.R. China; Shandong Institute of Otolaryngology, Jinan, P.R. China; Shandong Provincial Key Laboratory of Otology, Jinan, P.R. China.
Shandong Provincial Hospital · CNShandong University · CNSoutheast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIn this study, using an Streptococcus pneumoniae-induced tympanosclerosis (TS) model, we explored the effects of captopril and losartan in the treatment of TS and the possible mechanisms. STUDY

designA prospective experimental animal study.

methodsWe set up the TS models in both guinea pig and wistar rat by inoculation of type-3 Streptococcus pneumoniae microorganisms and then treated the animals with the combining use of captopril and losartan. Otomicroscopy was employed to observe the development of TS. Auditory brainstem response was used to test the hearing function of animals. Hematoxylin-eosin and von Kossa staining were performed to determine the morphological changes and calcium depositions. The protein expressions of transforming growth factor β1 (TGF-β1) were assessed by western blot and immunohistochemistry staining, and the mRNA level of TGF-β1 was measured by quantitative reverse transcription- polymerase chain reaction.

resultsThe combining use of captopril and losartan attenuated TS responses in terms of a decrease in the TS incidence and the ABR threshold, a reduction of hyalinization and calcification in the middle ear mucosa and the thickness of the mucosa. In addition, the TGF-β1 expression was decreased at both protein and mRNA levels.

conclusionOur data indicate, for the first time, that the combining use of captopril and losartan obviously attenuates TS progress through inhibiting the overexpressing of TGF-β1.

Indexed as

Disease ProgressionAnimalsBlotting, WesternCalcinosisCalciumCaptoprilDisease Models, AnimalDrug Therapy, CombinationEar, MiddleGuinea PigsHearingImmunohistochemistryLosartanMaleMucous MembraneMyringosclerosisCalciumCaptoprilLosartanTransforming Growth Factor beta1

Identifiers

PMID25360706
PMCPMC4216096
OpenAlexW2061052840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.