ArticlePloS one2014
Antennal-expressed ammonium transporters in the malaria vector mosquito Anopheles gambiae.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Odorant receptor coexpression and multi-expression in the dengue mosquito.Nature communications · 2026Article
- Molecular Characterization, Evolution and Expression Analysis of Ammonium Transporter from Four Closely RelatedLife (Basel, Switzerland) · 2024Article
- Biological ammonium transporters from the Amt/Mep/Rh superfamily: mechanism, energetics, and technical limitations.Bioscience reports · 2024Review
- Expression and Functional Analysis ofAnimals : an open access journal from MDPI · 2023Article
- The antennal transcriptome of Triatoma infestans reveals substantial expression changes triggered by a blood meal.BMC genomics · 2022Article
- An ammonium transporter is a non-canonical olfactory receptor for ammonia.Current biology : CB · 2021Article
- Ammonium transporter AcAmt mutagenesis uncovers reproductive and physiological defects without impacting olfactory responses to ammonia in the malaria vector mosquito Anopheles coluzzii.Insect biochemistry and molecular biology · 2021Article
- Ammonium transporter expression in sperm of the disease vectorProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Molecular mechanisms of olfactory detection in insects: beyond receptors.Open biology · 2020Article
- Heterogeneous expression of the ammonium transporter AgAmt in chemosensory appendages of the malaria vector, Anopheles gambiae.Insect biochemistry and molecular biology · 2020Article
- Increased capture of Aedes aegypti (Linnaeus, 1762) (Diptera: Culicidae) by removing one ADULTRAP component.Revista da Sociedade Brasileira de Medicina Tropical · 2020Article
- Comparative transcriptome analysis of Apis mellifera antennae of workers performing different tasks.Molecular genetics and genomics : MGG · 2018Article
- Ammonia Excretion in an Osmoregulatory Syncytium Is Facilitated by AeAmt2, a Novel Ammonia Transporter inFrontiers in physiology · 2018Article
- The molecular sensory machinery of a Chagas disease vector: expression changes through imaginal moult and sexually dimorphic features.Scientific reports · 2017Article
- Horizontal gene transfer drives the evolution of Rh50 permeases in prokaryotes.BMC evolutionary biology · 2017Article
- The neurotranscriptome of the Aedes aegypti mosquito.BMC genomics · 2016Article
- Evolution of Electrogenic Ammonium Transporters (AMTs).Frontiers in plant science · 2016Article
- Reception of odors and repellents in mosquitoes.Current opinion in neurobiology · 2015Review
- Mechanism of ammonia excretion in the freshwater leech Nephelopsis obscura: characterization of a primitive Rh protein and effects of high environmental ammonia.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The principal Afrotropical malaria vector mosquito, Anopheles gambiae remains a significant threat to human health. In this anthropophagic species, females detect and respond to a range of human-derived volatile kairomones such as ammonia, lactic acid, and other carboxylic acids in their quest for blood meals. While the molecular underpinnings of mosquito olfaction and host seeking are becoming better understood, many questions remain unanswered. In this study, we have identified and characterized two candidate ammonium transporter genes, AgAmt and AgRh50 that are expressed in the mosquito antenna and may contribute to physiological and behavioral responses to ammonia, which is an important host kairomone for vector mosquitoes. AgAmt transcripts are highly enhanced in female antennae while a splice variant of AgRh50 appears to be antennal-specific. Functional expression of AgAmt in Xenopus laevis oocytes facilitates inward currents in response to both ammonium and methylammonium, while AgRh50 is able to partially complement a yeast ammonium transporter mutant strain, validating their conserved roles as ammonium transporters. We present evidence to suggest that both AgAmt and AgRh50 are in vivo ammonium transporters that are important for ammonia sensitivity in An. gambiae antennae, either by clearing ammonia from the sensillar lymph or by facilitating sensory neuron responses to environmental exposure. Accordingly, AgAmt and AgRh50 represent new and potentially important targets for the development of novel vector control strategies.
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