Evidence map›Paper›PMID 25360597›Full record

ArticlePloS one2014

Ultrasonographic evaluation of cerebral arterial and venous haemodynamics in multiple sclerosis: a case-control study.

Pasquale Marchione, Manuela Morreale, Patrizia Giacomini, Chiara Izzo, Simona Pontecorvo, Marta Altieri, Silvia Bernardi, Marco Frontoni, Ada Francia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Abnormal venous postural control: multiple sclerosis-specific change related to gray matter pathology or age-related neurodegenerative phenomena?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Pasquale MarchioneNeurovascular Diagnosis Unit, Department of Medical and Surgical Sciences and Biotechnology - Section of Neurology, Sapienza, University of Rome, Rome, Italy; Department of Clinical Neurosciences, Neurological Centre of Latium - Institute of Neurosciences, Rome, Italy.
Manuela MorrealeNeurovascular Diagnosis Unit, Department of Medical and Surgical Sciences and Biotechnology - Section of Neurology, Sapienza, University of Rome, Rome, Italy; Multiple Sclerosis Center, Department of Neurology and Psychiatry, Sapienza, University of Rome, Rome, Italy.
Patrizia GiacominiNeurovascular Diagnosis Unit, Department of Medical and Surgical Sciences and Biotechnology - Section of Neurology, Sapienza, University of Rome, Rome, Italy.
Chiara IzzoNeurovascular Diagnosis Unit, Department of Medical and Surgical Sciences and Biotechnology - Section of Neurology, Sapienza, University of Rome, Rome, Italy; Department of Clinical Neurosciences, Neurological Centre of Latium - Institute of Neurosciences, Rome, Italy.
Simona PontecorvoMultiple Sclerosis Center, Department of Neurology and Psychiatry, Sapienza, University of Rome, Rome, Italy; Istituto di Ricerca e Cura a Carattere Scientifico - Neuromed, Pozzilli (Isernia), Italy.
Marta AltieriMultiple Sclerosis Center, Department of Neurology and Psychiatry, Sapienza, University of Rome, Rome, Italy.
Silvia BernardiMultiple Sclerosis Center, Department of Neurology and Psychiatry, Sapienza, University of Rome, Rome, Italy.
Marco FrontoniMultiple Sclerosis Center, Department of Neurology and Psychiatry, Sapienza, University of Rome, Rome, Italy.
Ada FranciaMultiple Sclerosis Center, Department of Neurology and Psychiatry, Sapienza, University of Rome, Rome, Italy.
Sapienza University of Rome · ITNeuroscience Institute · ITIstituto Neurologico Mediterraneo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAlthough recent studies excluded an association between Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis (MS), controversial results account for some cerebrovascular haemodynamic impairment suggesting a dysfunction of cerebral autoregulation mechanisms. The aim of this cross-sectional, case-control study is to evaluate cerebral arterial inflow and venous outflow by means of a non-invasive ultrasound procedure in Relapsing Remitting (RR), Primary Progressive (PP) Multiple Sclerosis and age and sex-matched controls subjects. MATERIAL AND

methodsAll subjects underwent a complete extra-intracranial arterial and venous ultrasound assessment with a color-coded duplex sonography scanner and a transcranial doppler equipment, in both supine and sitting position by means of a tilting chair. Basal arterial and venous morphology and flow velocities, postural changes in mean flow velocities (MFV) of middle cerebral arteries (MCA), differences between cerebral venous outflow (CVF) in clinostatism and in the seated position (ΔCVF) and non-invasive cerebral perfusion pressure (CPP) were evaluated.

results85 RR-MS, 83 PP-MS and 82 healthy controls were included. ΔCVF was negative in 45/85 (52.9%) RR-MS, 63/83 (75.9%) PP-MS (p = 0.01) and 11/82 (13.4%) controls (p<0.001), while MFVs on both MCAs in sitting position were significantly reduced in RR-MS and PP-MS patients than in control, particularly in EDSS ≥ 5 subgroup (respectively, 42/50, 84% vs. 66/131, 50.3%, p<0.01 and 48.3 ± 2 cm/s vs. 54.6 ± 3 cm/s, p = 0.01). No significant differences in CPP were observed within and between groups.

conclusionsThe quantitative evaluation of cerebral blood flow (CBF) and CVF and their postural dependency may be related to a dysfunction of autonomic nervous system that seems to characterize more disabled MS patients. It's not clear whether the altered postural control of arterial inflow and venous outflow is a specific MS condition or simply an "epiphenomenon" of neurodegenerative events.

Indexed as

HemodynamicsAdultCase-Control StudiesCerebral VeinsFemaleHumansMaleMultiple SclerosisUltrasonography

Identifiers

PMID25360597
PMCPMC4216015
OpenAlexW2313388364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.