ArticleBiomedical optics express2014
Shape-parameterized diffuse optical tomography holds promise for sensitivity enhancement of fluorescence molecular tomography.
Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- CW-fDOT with a standard optical brain model: improving hemodynamic sensitivity and functional localization.Neurophotonics · 2026Article
- Development of a statistically standardized optical digital wrist model through integrated MRI-diffuse optical imaging methodology.Journal of biomedical optics · 2025Article
- Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging.Journal of biomedical optics · 2019Article
- Parameterized level-set based pharmacokinetic fluorescence optical tomography using the regularized Gauss-Newton filter.Journal of biomedical optics · 2018Article
- Deep learning-based mesoscopic fluorescence molecular tomography: anJournal of medical imaging (Bellingham, Wash.) · 2018Article
- Reconstruction of fluorescence molecular tomography with a cosinoidal level set method.Biomedical engineering online · 2017Article
- Region-based diffuse optical tomography with registered atlas:Biomedical optics express · 2016Article
- Shape-based reconstruction of dynamic fluorescent yield with a level set method.Biomedical engineering online · 2016Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
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Abstract
A fundamental approach to enhancing the sensitivity of the fluorescence molecular tomography (FMT) is to incorporate diffuse optical tomography (DOT) to modify the light propagation modeling. However, the traditional voxel-based DOT has been involving a severely ill-posed inverse problem and cannot retrieve the optical property distributions with the acceptable quantitative accuracy and spatial resolution. Although, with the aid of an anatomical imaging modality, the structural-prior-based DOT method with either the hard- or soft-prior scheme holds promise for in vivo acquiring the optical background of tissues, the low robustness of the hard-prior scheme to the segmentation error and inferior performance of the soft-prior one in the quantitative accuracy limit its further application. We propose in this paper a shape-parameterized DOT method for not only effectively determining the regional optical properties but potentially achieving reasonable structural amelioration, lending itself to FMT for comparably improved recovery of fluorescence distribution.
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