Evidence map›Paper›PMID 25360367›Full record

ArticleBiomedical optics express2014

Depth resolved hyperspectral imaging spectrometer based on structured light illumination and Fourier transform interferometry.

Heejin Choi, Dushan Wadduwage, Paul T Matsudaira, Peter T C So

Abstract read
In one paragraph

Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Heejin ChoiDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Dushan WadduwageBioSym, Singapore-MIT Alliance for Research and Technology, Singapore 138602, Singapore ; Department of Biological Sciences, National University of Singapore, Singapore 138602, Singapore.
Paul T MatsudairaDepartment of Biological Sciences, National University of Singapore, Singapore 138602, Singapore.
Peter T C SoDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA ; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA ; BioSym, Singapore-MIT Alliance for Research and Technology, Singapore 138602, Singapore ; Laser Biomedical Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Funding

Wide-Field Short-Wave Infrared (SWIR) multiphoton (MP) tissue imagingP41EB015871 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2012 to 2021
$11.3M
In Vivo Imaging of Neuronal Plasticity in Visual CortexR01EY017656 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NEDIVI, ELLY, SO, PETER T. · 2008 to 2014
$2.5M
Regenerative Healing Using ECM Based ScaffoldsR01NS051320 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YANNAS, IOANNIS V · 2006 to 2009
$1.6M
High Throughput Manufacturing for Three-Dimensional Microfluidic DevicesR44EB012415 · NIBIB · FEMTOFAB, INC. · PI JANG, YUN-HO · 2011 to 2013
$849k
NEI NIH HHS R01 EY017656NIBIB NIH HHS P41 EB015871NIBIB NIH HHS R44 EB012415NINDS NIH HHS R01 NS051320
6 · The paper itself

Abstract

A depth resolved hyperspectral imaging spectrometer can provide depth resolved imaging both in the spatial and the spectral domain. Images acquired through a standard imaging Fourier transform spectrometer do not have the depth-resolution. By post processing the spectral cubes (x, y, λ) obtained through a Sagnac interferometer under uniform illumination and structured illumination, spectrally resolved images with depth resolution can be recovered using structured light illumination algorithms such as the HiLo method. The proposed scheme is validated with in vitro specimens including fluorescent solution and fluorescent beads with known spectra. The system is further demonstrated in quantifying spectra from 3D resolved features in biological specimens. The system has demonstrated depth resolution of 1.8 μm and spectral resolution of 7 nm respectively.

Indexed as

(170.2520) Fluorescence microscopy(170.6900) Three-dimensional microscopy(300.6300) Spectroscopy, Fourier transforms

Identifiers

PMID25360367
PMCPMC4206319

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.