ArticleBiomedical optics express2014
Differentiation of ex vivo human breast tissue using polarization-sensitive optical coherence tomography.
Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Polarisation-Sensitive Optical Coherence Tomography for Surgical Margin Evaluation and Diagnosis of Excised Canine Cutaneous and Subcutaneous Tumours.Veterinary and comparative oncology · 2026Article
- Deep UV laser scanning microscopy with integrated 1050 nm spectral-domain optical coherence tomography for multi-contrast tissue imaging.Biomedical optics express · 2025Article
- Polarisation Sensitive Optical Coherence Tomography Image Characteristics for Gastrointestinal Tumours and Normal Tissues at Surgical Margins in Dogs.Veterinary and comparative oncology · 2025Article
- OCT in Oncology and Precision Medicine: From Nanoparticles to Advanced Technologies and AI.Bioengineering (Basel, Switzerland) · 2025Review
- Optical Coherence Tomography Angiography, Elastography, and Attenuation Imaging for Evaluation of Liver Regeneration.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Polarization-sensitive optical coherence tomography for renal tumor detection inOptics and lasers in engineering · 2024Article
- Polarization-artifact reduction and accuracy improvement of Jones-matrix polarization-sensitive optical coherence tomography by multi-focus-averaging based multiple scattering reduction.Biomedical optics express · 2024Article
- Article
- Multi-class classification of breast tissue using optical coherence tomography and attenuation imaging combined via deep learning.Biomedical optics express · 2022Article
- Molecular Contrast Optical Coherence Tomography and Its Applications in Medicine.International journal of molecular sciences · 2022Review
- Birefringent tissue-mimicking phantom for polarization-sensitive optical coherence tomography imaging.Journal of biomedical optics · 2022Article
- Evaluating optical coherence tomography for surgical margin assessment of canine mammary tumours.Veterinary and comparative oncology · 2021Article
- Compressive sensing for polarization sensitive optical coherence tomography.Journal of physics D: Applied physics · 2021Article
- Synthetic polarization-sensitive optical coherence tomography by deep learning.NPJ digital medicine · 2021Article
- Computational adaptive optics for polarization-sensitive optical coherence tomography.Optics letters · 2021Article
- Differentiation of breast tissue types for surgical margin assessment using machine learning and polarization-sensitive optical coherence tomography.Biomedical optics express · 2021Article
- Diagnostic Accuracy of Cross-Polarization OCT and OCT-Elastography for Differentiation of Breast Cancer Subtypes: Comparative Study.Diagnostics (Basel, Switzerland) · 2020Article
- Influence of tissue fixation on depth-resolved birefringence of oral cavity tissue samples.Journal of biomedical optics · 2020Article
- Automated fast computational adaptive optics for optical coherence tomography based on a stochastic parallel gradient descent algorithm.Optics express · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
Successful treatment of breast cancer typically requires surgical removal of the tumor. Optical coherence tomography (OCT) has been previously developed for real-time imaging of the surgical margin. However, it can be difficult to distinguish between normal stromal tissue and cancer tissue based on scattering intensity and structure alone. Polarization-sensitive optical coherence tomography (PS-OCT) is sensitive to form birefringence of biological tissue. We report on the development of a high-speed PS-OCT system and imaging of ex vivo human breast tissue, showing enhanced contrast between healthy and cancerous tissues based upon collagen content confirmed with corresponding histology. These results demonstrate the feasibility of using PS-OCT to supplement structural OCT as a possible method for intraoperative tumor margin evaluation.
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