Evidence map›Paper›PMID 25360357›Full record

ArticleBiomedical optics express2014

Sub-diffusive scattering parameter maps recovered using wide-field high-frequency structured light imaging.

Stephen Chad Kanick, David M McClatchy, Venkataramanan Krishnaswamy, Jonathan T Elliott, Keith D Paulsen, Brian W Pogue

Abstract read
In one paragraph

Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review of structured light in diffuse optical imaging.Journal of biomedical optics · 2018
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stephen Chad KanickThayer School of Engineering, Dartmouth College, Hanover, NH, 03755 USA.
David M McClatchyThayer School of Engineering, Dartmouth College, Hanover, NH, 03755 USA.
Venkataramanan KrishnaswamyThayer School of Engineering, Dartmouth College, Hanover, NH, 03755 USA.
Jonathan T ElliottThayer School of Engineering, Dartmouth College, Hanover, NH, 03755 USA.
Keith D PaulsenThayer School of Engineering, Dartmouth College, Hanover, NH, 03755 USA.
Brian W PogueThayer School of Engineering, Dartmouth College, Hanover, NH, 03755 USA.

Funding

Fluorescence Imaging to Optimize Cancer TherapyR01CA109558 · NCI · DARTMOUTH COLLEGE · PI POGUE, BRIAN WILLIAM · 2005 to 2015
$2.8M
Quantitative optical dosimetry of magnetic nanoparticle cancer treatmentsK25CA164248 · NCI · DARTMOUTH COLLEGE · PI KANICK, STEPHEN CHAD · 2013 to 2015
$498k
NCI NIH HHS K25 CA164248NCI NIH HHS R01 CA109558
6 · The paper itself

Abstract

This study investigates the hypothesis that structured light reflectance imaging with high spatial frequency patterns [Formula: see text] can be used to quantitatively map the anisotropic scattering phase function distribution [Formula: see text] in turbid media. Monte Carlo simulations were used in part to establish a semi-empirical model of demodulated reflectance ([Formula: see text]) in terms of dimensionless scattering [Formula: see text] and [Formula: see text], a metric of the first two moments of the [Formula: see text] distribution. Experiments completed in tissue-simulating phantoms showed that simultaneous analysis of [Formula: see text] spectra sampled at multiple [Formula: see text] in the frequency range [0.05-0.5] [Formula: see text] allowed accurate estimation of both [Formula: see text] in the relevant tissue range [0.4-1.8] [Formula: see text], and [Formula: see text] in the range [1.4-1.75]. Pilot measurements of a healthy volunteer exhibited [Formula: see text]-based contrast between scar tissue and surrounding normal skin, which was not as apparent in wide field diffuse imaging. These results represent the first wide-field maps to quantify sub-diffuse scattering parameters, which are sensitive to sub-microscopic tissue structures and composition, and therefore, offer potential for fast diagnostic imaging of ultrastructure on a size scale that is relevant to surgical applications.

Indexed as

(170.3660) Light propagation in tissues(170.3880) Medical and biological imaging(170.6510) Spectroscopy, tissue diagnostics(170.7050) Turbid media(290.0290) Scattering

Identifiers

PMID25360357
PMCPMC4206309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.