ArticleLupus science & medicine2014
Pregnancy outcomes among African-American patients with systemic lupus erythematosus compared with controls.
Article in Lupus science & medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Risk of adverse pregnancy outcomes prior to the onset of an autoimmune rheumatic disease: a systematic review.Rheumatology (Oxford, England) · 2023Pooled it
- Preeclampsia in systemic lupus erythematosus pregnancy: a systematic review and meta-analysis.Clinical rheumatology · 2020Pooled it
- EULAR recommendations for women's health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome.Annals of the rheumatic diseases · 2017Guideline
- Reproductive outcomes following hydroxychloroquine use for autoimmune diseases: a systematic review and meta-analysis.British journal of clinical pharmacology · 2016Pooled it
- Adverse pregnancy outcome associations among women prior to a diagnosis of systemic lupus erythematosus.Frontiers in lupus · 2026Article
- A nomogram for predicting the adverse pregnancy outcomes of systemic lupus erythematosus: a single-center study.Clinical rheumatology · 2025Article
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- Article
- Understanding the Pathophysiology of Preeclampsia: Exploring the Role of Antiphospholipid Antibodies and Future Directions.Journal of clinical medicine · 2024Review
- Systemic Lupus Erythematosus Delivery Outcomes Are Unchanged Across Three Decades.ACR open rheumatology · 2022Article
- Adverse Perinatal Outcomes Before and After Diagnosis of Systemic Lupus Erythematosus Among African American Women.Arthritis care & research · 2022Article
- Systemic Lupus Erythematosus and Pregnancy: a Portuguese Case-Control Study.Clinical reviews in allergy & immunology · 2022Article
- Autoimmunity: Are we asking the right question?Frontiers in immunology · 2022Article
- Infertility Among African American Women With Systemic Lupus Erythematosus Compared to Healthy Women: A Pilot Study.Arthritis care & research · 2020Article
- Pregnancy outcomes among Chinese women with and without systemic lupus erythematosus: a retrospective cohort study.BMJ open · 2018Article
- What to Expect When Expecting With Systemic Lupus Erythematosus (SLE): A Population-Based Study of Maternal and Fetal Outcomes in SLE and Pre-SLE.Arthritis care & research · 2016Article
- Article
- I too, am America: a review of research on systemic lupus erythematosus in African-Americans.Lupus science & medicine · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveIn a study of Gullah African-Americans, we compared pregnancy outcomes before and after systemic lupus erythematosus (SLE) diagnosis to controls to test whether there is a predisease state that negativelyaffects pregnancy outcomes.
designCases and controls reporting at least one pregnancy were included. Controls were all Gullah African-American females. We collected demographic, socioeconomic and pregnancy data. We modelled pregnancy outcome associations with case status using multiple logistic regression to calculate ORs.
resultsAfter adjustment for age, years of education, medical coverage and pregnancy number, compared with controls, cases were more likely to have any adverse outcome (OR 2.35, 95% CI 1.78 to 3.10), including stillbirth (OR 4.55, 95% CI 1.53 to 13.50), spontaneous abortion (OR 2.05, 95% CI 1.40 to 3.00), preterm birth (OR 2.58, 95% CI 1.58 to 4.20), low birth weight (OR 2.64, 95% CI 1.61 to 4.34) and preeclampsia (OR 1.80, 95% CI 1.08 to 3.01). The odds of adverse pregnancy outcomes all increased after SLE diagnosis compared with before diagnosis, even after adjustment for age, years of education, pregnancy number and medical coverage.
conclusionFrom a large cohort of African-American women, our findings suggest there may be a predisease state that predisposes to adverse pregnancy outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.