ArticleUnited European gastroenterology journal2014
Serial intralesional injections of infliximab in small bowel Crohn's strictures are feasible and might lower inflammation.
Article in United European gastroenterology journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Systematic review: medical therapy for fibrostenosing Crohn's disease.Alimentary pharmacology & therapeutics · 2020Pooled it
- Review on Advances in Pediatric Endoscopy in the Management of Inflammatory Bowel Disease.Current pediatric reviews · 2025Review
- Endoscopic Management of Strictures in Crohn's Disease: An Unsolved Case.Journal of clinical medicine · 2024Review
- Fibrostenosing Crohn's Disease: Pathogenetic Mechanisms and New Therapeutic Horizons.International journal of molecular sciences · 2024Review
- Local injection of infliximab into calcinosis lesions in patients with juvenile dermatomyositis (JDM): a clinical trial.Pediatric rheumatology online journal · 2024Article
- Advancing therapeutic frontiers: a pipeline of novel drugs for luminal and perianal Crohn's disease management.Therapeutic advances in gastroenterology · 2024Review
- Endoscopic Management of Luminal Strictures: Beyond Dilation.Digestive diseases and sciences · 2022Review
- Current and Emerging Approaches to the Diagnosis and Treatment of Crohn's Disease Strictures.Gastroenterology & hepatology · 2022Article
- Endoscopic balloon dilation for management of stricturing Crohn's disease in children.World journal of gastrointestinal endoscopy · 2021Article
- Strictures in Crohn's Disease: From Pathophysiology to Treatment.Digestive diseases and sciences · 2020Review
- Review: Local Tumor Necrosis Factor-α Inhibition in Inflammatory Bowel Disease.Pharmaceutics · 2020Review
- Towards the Oral Treatment of Ileo-Colonic Inflammatory Bowel Disease with Infliximab Tablets: Development and Validation of the Production Process.Pharmaceutics · 2019Article
- Endoscopic management of Crohn's strictures.World journal of gastroenterology · 2018Review
- Role of endoscopy in inflammatory bowel disease.Gastroenterology report · 2018Review
- Review of local injection of anti-TNF for perianal fistulising Crohn's disease.International journal of colorectal disease · 2017Review
- Surgical Considerations in the Treatment of Small Bowel Crohn's Disease.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Review
- Biodegradable stents for the treatment of bowel strictures in Crohn's disease: technical results and challenges.Endoscopy international open · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCrohn's disease can cause strictures throughout the gastrointestinal tract. Endoscopic balloon dilatation is a well-established treatment, but recurrence is seen in up to three out of four cases. Infliximab is playing an increasingly important role in the modern systemic treatment of severe Crohn's disease. Combining the anti-inflammatory effects of infliximab with the proven effect of endoscopic balloon dilatation could possibly improve outcome. In small studies, intralesional injections in perianal fistulas have been effective and endoscopic injection therapy in colonic strictures is feasible.
objectiveWe wanted to assess whether serial intralesional injection of infliximab in small bowel strictures is feasible and reduces local inflammation.
methodsWe included six patients with Crohn's disease and inflammatory small bowel strictures. They were treated with endoscopic serial balloon dilatation. Subsequent to each dilatation, 40 mg infliximab was injected submucosally. A modified simplified endoscopic score for Crohn's disease was used for the involved area before the initial treatment and at the final follow-up after six months. Complications and development of symptoms were registered.
resultsBalloon dilatation and serial injection of infliximab were accomplished in five out of six patients. One patient completed the serial balloon dilatations and follow-up but received only one infliximab injection. The modified simplified endoscopic score for Crohn's disease decreased in all patients. There were no adverse events registered and all patients described themselves as feeling well.
conclusionsCombining balloon dilatation of strictures with serial intralesional injection of infliximab in Crohn's disease of the small bowel is feasible and seems successful in reducing inflammation.
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Registered trials
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