Evidence map›Paper›PMID 25360160›Full record

ArticleJournal of cheminformatics2014

BioPhytMol: a drug discovery community resource on anti-mycobacterial phytomolecules and plant extracts.

Arun Sharma, Prasun Dutta, Maneesh Sharma, Neeraj Kumar Rajput, Bhavna Dodiya, John J Georrge, Trupti Kholia, OSDD Consortium, Anshu Bhardwaj

Abstract read
In one paragraph

Article in Journal of cheminformatics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Translational Informatics for Natural Products as Antidepressant Agents.Frontiers in cell and developmental biology · 2021
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Arun SharmaOpen Source Drug Discovery (OSDD) Unit, Council of Scientific and Industrial Research, New Delhi, India.
Prasun DuttaOpen Source Drug Discovery (OSDD) Unit, Council of Scientific and Industrial Research, New Delhi, India.
Maneesh SharmaSt. Stephens College, University of Delhi, New Delhi, India.
Neeraj Kumar RajputOpen Source Drug Discovery (OSDD) Unit, Council of Scientific and Industrial Research, New Delhi, India.
Bhavna DodiyaDepartment of Applied Mathematics and Bioinformatics, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat India.
John J GeorrgeDepartment of Bioinformatics, Christ College, Rajkot, Gujarat India ; Department of Biochemistry and Molecular Biology, University Clinic of Bonn (UKB), University of Bonn, Bonn, Germany.
Trupti KholiaDepartment of Bioinformatics, Christ College, Rajkot, Gujarat India.
OSDD Consortium
Anshu BhardwajOpen Source Drug Discovery (OSDD) Unit, Council of Scientific and Industrial Research, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTuberculosis (TB) is the second leading cause of death from a single infectious organism, demanding attention towards discovery of novel anti-tubercular compounds. Natural products or their derivatives have provided more than 50% of all existing drugs, offering a chemically diverse space for discovery of novel drugs. DESCRIPTION: BioPhytMol has been designed to systematically curate and analyze the anti-mycobacterial natural product chemical space. BioPhytMol is developed as a drug-discovery community resource with anti-mycobacterial phytomolecules and plant extracts. Currently, it holds 2582 entries including 188 plant families (692 genera and 808 species) from global flora, manually curated from literature. In total, there are 633 phytomolecules (with structures) curated against 25 target mycobacteria. Multiple analysis approaches have been used to prioritize the library for drug-like compounds, for both whole cell screening and target-based approaches. In order to represent the multidimensional data on chemical diversity, physiochemical properties and biological activity data of the compound library, novel approaches such as the use of circular graphs have been employed.

conclusionBioPhytMol has been designed to systematically represent and search for anti-mycobacterial phytochemical information. Extensive compound analyses can also be performed through web-application for prioritizing drug-like compounds. The resource is freely available online at http://ab-openlab.csir.res.in/biophytmol/. Graphical AbstractBioPhytMol: a drug discovery community resource on anti-mycobacterial phytomolecules and plant extracts generated using Crowdsourcing. The platform comprises of manually curated data on antimycobacterial natural products along with tools to perform structure similarity and visualization. The platform allows for prioritization of drug like natural products for antimycobacterial drug discovery.

Indexed as

Anti-mycobacterialAnti-TBAnti-tubercularBioPhytMolCrowdsourcingDrug discoveryTBTuberculosis

Identifiers

PMID25360160
PMCPMC4206768

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.