ReviewFrontiers in cellular neuroscience2014
Hemichannel composition and electrical synaptic transmission: molecular diversity and its implications for electrical rectification.
Review in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Defining the electrical synapse.Nature reviews. Neuroscience · 2026Review
- Configuration of electrical synapses filters sensory information to drive behavioral choices.Cell · 2025Article
- Article
- Fibration symmetries and cluster synchronization in the Caenorhabditis elegans connectome.PloS one · 2024Article
- The Caenorhabditis elegans innexin INX-20 regulates nociceptive behavioral sensitivity.Genetics · 2023Article
- A compact multi-functional model of the rabbit atrioventricular node with dual pathways.Frontiers in physiology · 2023Article
- Gap junction Delta-2b (Frontiers in cell and developmental biology · 2023Article
- Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate.Cancers · 2021Article
- Neuronal Switching between Single- and Dual-Network Activity via Modulation of Intrinsic Membrane Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Understanding the Molecular and Cell Biological Mechanisms of Electrical Synapse Formation.Frontiers in neuroanatomy · 2020Article
- INX-18 and INX-19 play distinct roles in electrical synapses that modulate aversive behavior in Caenorhabditis elegans.PLoS genetics · 2019Article
- Beyond plasticity: the dynamic impact of electrical synapses on neural circuits.Nature reviews. Neuroscience · 2019Review
- Electrical coupling between A17 cells enhances reciprocal inhibitory feedback to rod bipolar cells.Scientific reports · 2018Article
- Two Forms of Electrical Transmission Between Neurons.Frontiers in molecular neuroscience · 2018Article
- Asymmetry of an Intracellular Scaffold at Vertebrate Electrical Synapses.Current biology : CB · 2017Article
- Article
- A structural and functional comparison of gap junction channels composed of connexins and innexins.Developmental neurobiology · 2017Review
- Gap junctional signaling in pattern regulation: Physiological network connectivity instructs growth and form.Developmental neurobiology · 2017Review
- The electrical synapse: Molecular complexities at the gap and beyond.Developmental neurobiology · 2017Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Unapposed hemichannels (HCs) formed by hexamers of gap junction proteins are now known to be involved in various cellular processes under both physiological and pathological conditions. On the other hand, less is known regarding how differences in the molecular composition of HCs impact electrical synaptic transmission between neurons when they form intercellular heterotypic gap junctions (GJs). Here we review data indicating that molecular differences between apposed HCs at electrical synapses are generally associated with rectification of electrical transmission. Furthermore, this association has been observed at both innexin and connexin (Cx) based electrical synapses. We discuss the possible molecular mechanisms underlying electrical rectification, as well as the potential contribution of intracellular soluble factors to this phenomenon. We conclude that asymmetries in molecular composition and sensitivity to cellular factors of each contributing hemichannel can profoundly influence the transmission of electrical signals, endowing electrical synapses with more complex functional properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.