ArticleG3 (Bethesda, Md.)2014
Quantitative trait locus mapping of melanization in the plant pathogenic fungus Zymoseptoria tritici.
Article in G3 (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 101 citations in OpenAlex.
- A new method to measure ECPest management science · 2026Article
- Recurrent Chromosome Destabilization Through Repeat-Mediated Rearrangements in a Fungal Pathogen.Genome biology and evolution · 2026Article
- Mapping genomic regions associated with temperature stress in the wheat pathogen Zymoseptoria tritici.G3 (Bethesda, Md.) · 2025Article
- Quantitative trait locus mapping of osmotic stress response in the fungal wheat pathogen Zymoseptoria tritici.G3 (Bethesda, Md.) · 2023Article
- Combined reference-free and multi-reference based GWAS uncover cryptic variation underlying rapid adaptation in a fungal plant pathogen.PLoS pathogens · 2023Article
- Fungal plant pathogen "mutagenomics" reveals tagged and untagged mutations inFrontiers in plant science · 2023Article
- Quantitative and qualitative plant-pathogen interactions call upon similar pathogenicity genes with a spectrum of effects.Frontiers in plant science · 2023Article
- Genome-wide association mapping reveals genes underlying population-level metabolome diversity in a fungal crop pathogen.BMC biology · 2022Article
- Machine-learning predicts genomic determinants of meiosis-driven structural variation in a eukaryotic pathogen.Nature communications · 2021Article
- Tolerance to oxidative stress is associated with both oxidative stress response and inherent growth in a fungal wheat pathogen.Genetics · 2021Article
- Maintenance of variation in virulence and reproduction in populations of an agricultural plant pathogen.Evolutionary applications · 2021Article
- Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence.PLoS genetics · 2021Article
- The Genetic Architecture of Emerging Fungicide Resistance in Populations of a Global Wheat Pathogen.Genome biology and evolution · 2020Article
- The role of vegetative cell fusions in the development and asexual reproduction of the wheat fungal pathogen Zymoseptoria tritici.BMC biology · 2020Article
- The wheat pathogen Zymoseptoria tritici senses and responds to different wavelengths of light.BMC genomics · 2020Article
- An Avirulence Gene Cluster in the Wheat Stripe Rust Pathogen (Puccinia striiformis f. sp.mSphere · 2020Article
- MADS-Box Transcription FactorFrontiers in microbiology · 2020Article
- Gene cluster conservation identifies melanin and perylenequinone biosynthesis pathways in multiple plant pathogenic fungi.Environmental microbiology · 2019Article
- Highly flexible infection programs in a specialized wheat pathogen.Ecology and evolution · 2019Article
- Precision Phenotyping Reveals Novel Loci for Quantitative Resistance to Septoria Tritici Blotch.Plant phenomics (Washington, D.C.) · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melanin plays an important role in virulence and antimicrobial resistance in several fungal pathogens. The wheat pathogen Zymoseptoria tritici is important worldwide, but little is known about the genetic architecture of pathogenicity, including the production of melanin. Because melanin production can exhibit complex inheritance, we used quantitative trait locus (QTL) mapping in two crosses to identify the underlying genes. Restriction site-associated DNA sequencing was used to genotype 263 (cross 1) and 261 (cross 2) progeny at ~8500 single-nucleotide polymorphisms and construct two dense linkage maps. We measured gray values, representing degrees of melanization, for single-spore colonies growing on Petri dishes by using a novel image-processing approach that enabled high-throughput phenotyping. Because melanin production can be affected by stress, each offspring was grown in two stressful environments and one control environment. We detected six significant QTL in cross 1 and nine in cross 2, with three QTL shared between the crosses. Different QTL were identified in different environments and at different colony ages. By obtaining complete genome sequences for the four parents and analyzing sequence variation in the QTL confidence intervals, we identified 16 candidate genes likely to affect melanization. One of these candidates was PKS1, a polyketide synthase gene known to play a role in the synthesis of dihydroxynaphthalene melanin. Three candidate quantitative trait nucleotides were identified in PKS1. Many of the other candidate genes were not previously associated with melanization.
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