ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2014
Social peptides: measuring urinary oxytocin and vasopressin in a home field study of older adults at risk for dehydration.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Cortisol and Catecholamine Concentrations Are Affected by Repeated Relocations of Adult Female Rhesus Monkeys (Macaca mulatta).American journal of primatology · 2025Article
- Intranasal Oxytocin and Pain Reduction: Testing a Social Cognitive Mediation Model.Brain sciences · 2023Article
- Attachment across the lifespan: Examining the intersection of pair bonding neurobiology and healthy aging.Neuroscience and biobehavioral reviews · 2023Review
- Advances in human oxytocin measurement: challenges and proposed solutions.Molecular psychiatry · 2023Review
- What are oxytocin assays measuring? Epitope mapping, metabolites, and comparisons of wildtype & knockout mouse urine.Psychoneuroendocrinology · 2022Article
- Analytical and physiological validation of an enzyme immunoassay to measure oxytocin in dog, wolf, and human urine samples.Scientific reports · 2021Article
- Validation of a commercial enzyme immunoassay to assess urinary oxytocin in humans.Endocrine connections · 2021Article
- Age and intranasal oxytocin effects on trust-related decisions after breach of trust: Behavioral and brain evidence.Psychology and aging · 2021Article
- Mothers' and fathers' joint profiles for testosterone and oxytocin in a small-scale fishing-farming community: Variation based on marital conflict and paternal contributions.Brain and behavior · 2019Article
- Exploring associations between perinatal depression, anxiety, and urinary oxytocin levels in Latinas.Archives of women's mental health · 2019Article
- Canine Endogenous Oxytocin Responses to Dog-Walking and Affiliative Human⁻Dog Interactions.Animals : an open access journal from MDPI · 2019Article
- Frequent Sexual Activity Predicts Specific Cognitive Abilities in Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2019Article
- Oxytocin and Social Bonds: The Role of Oxytocin in Perceptions of Romantic Partners' Bonding Behavior.Psychological science · 2017Article
- Plasma and Urinary Oxytocin Trajectories in Extremely Premature Infants During NICU Hospitalization.Biological research for nursing · 2017Article
- Neuroendocrine control in social relationships in non-human primates: Field based evidence.Hormones and behavior · 2017Review
- Oxytocin and bone status in men: analysis of the MINOS cohort.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectivesWe present the novel urine collection method used during in-home interviews of a large population representative of older adults in the United States (aged 62-91, the National Social Life, Health and Aging Project). We also present a novel assay method for accurately measuring urinary peptides oxytocin (OT) and vasopressin (AVP), hormones that regulate social behaviors, stress, and kidney function.
methodRespondents in a randomized substudy (N = 1,882) used airtight containers to provide urine specimens that were aliquoted, stored under frozen refrigerant packs and mailed overnight for frozen storage (-80 °C). Assays for OT, AVP, and creatinine, including freeze-thaw cycles, were refined and validated. Weighted values estimated levels in the older U.S. population.
resultsOlder adults had lower OT, but higher AVP, without the marked gender differences seen in young adults. Mild dehydration, indicated by creatinine, specific gravity, acidity, and AVP, produced concentrated urine that interfered with the OT assay, yielding falsely high values (18% of OT). Creatinine levels (≥ 1.4 mg/ml) identified such specimens that were diluted to solve the problem. In contrast, the standard AVP assay was unaffected (97% interpretable) and urine acidity predicted specimens with low OT concentrations. OT and AVP assays tolerated 2 freeze-thaw cycles, making this protocol useful in a variety of field conditions. DISCUSSION: These novel protocols yielded interpretable urinary OT and AVP values, with sufficient variation for analyzing their social and physiological associations. The problem of mild dehydration is also likely common in animal field studies, which may also benefit from these collection and assay protocols.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.