ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2014
The utility and dynamics of salivary sex hormone measurements in the National Social Life, Health, and Aging Project, Wave 2.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Association between salivary and blood hormone concentrations using an automated electrochemiluminescence immunoassay technique: Challenges and pitfalls.Experimental physiology · 2025Article
- Exploring the Moderation Effects of Race on the Relationship Among Sex Hormones, Biomarkers, and Psychological Symptoms in Female Older Adults.Clinical nursing research · 2025Article
- Sex Differences in Sexual Motivation Among U.S. Residents 57-85 Years of Age.Archives of sexual behavior · 2025Article
- Female RNA concussion (FeRNAC) study: assessing hormone profiles and salivary RNA in females with concussion by emergency departments in New Zealand: a study protocol.BMC neurology · 2024Article
- Hyposalivation but not Sjögren's syndrome associated with microbial dysbiosis in women.Frontiers in microbiology · 2023Article
- Aging-Related Metabolic Dysfunction in the Salivary Gland: A Review of the Literature.International journal of molecular sciences · 2021Review
- Article
- The rate of change in declining steroid hormones: a new parameter of healthy aging in men?Oncotarget · 2016Article
- Comorbidity and chronic conditions in the National Social Life, Health and Aging Project (NSHAP), Wave 2.The journals of gerontology. Series B, Psychological sciences and social sciences · 2014Article
- Survey field methods for expanded biospecimen and biomeasure collection in NSHAP Wave 2.The journals of gerontology. Series B, Psychological sciences and social sciences · 2014Article
- Salivary Menopausal Markers and Oral Health Status - A Hidden Hook Up.Journal of mid-life healthArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesSex hormones affect physical, mental, and social health, yet their role in mediating social effects on aging is understudied. To facilitate such analyses with the National Social Life, Health & Aging Project Wave 2, we summarize the conceptual background, collection protocols, laboratory assays, and data analysis strategies for biologically active (free) levels of testosterone, estradiol, progesterone, and dehydroepiandrosterone (DHEA).
methodSaliva from passive drool was collected from returning Wave 1 respondents and non-respondents as well as their partners during an in-home interview. Specimens were frozen and sent to Dresden LabService GmbH for duplicate assays of biologically active steroids using identical assay kits from National Social Life, Health, and Aging Project (NSHAP) Wave 1 (SaliCap, Catalog No. RE69995). Overall, 2,772 testosterone, 2,504 estradiol, 2,714 progesterone, and 2,800 DHEA measurements are publically available for Wave 2 analyses. Through a series of weighted linear regressions, all 4 steroids are compared by gender and age and to Wave 1 measurements.
resultsMen had higher levels of both free testosterone and progesterone than women; women and men had the same levels of estradiol and DHEA. Both free testosterone and DHEA decreased with age. We also found significant wave effects for all 4 sex hormones.
conclusionNSHAP Waves 1 and 2 are the first U.S. probability sample studies to measure these 4 salivary sex hormones simultaneously, providing individual profiles 5 years apart. Wave 2 data demonstrate differences by gender and trends by age that are similar to those found in other saliva-based and serum-based studies of free steroid levels. The differences between waves arising from the change in assay laboratory need to be adjusted in future longitudinal analyses using NSHAP Wave 1 and Wave 2 steroid data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.